Anti-Human CD3E Recombinant Nanobody (SAA2242) is a recombinant nanobody targeting Human CD3E (clone SAA2242). Format: VHH-hFc (human host). Reactivity: Human. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA and flow cytometry. Purity: >95% as determined by SDS-PAGE. For research use only.
T-cell surface glycoprotein CD3 epsilon chain (CD3E) is a ~23 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. CD3E is the therapeutic target of blinatumomab (Blincyto).
Product Name:
Anti-Human CD3E Recombinant Nanobody (SAA2242)
Size:
50 µg, 100 µg, 1 mg
Product SKU:
GXRM04211
Target:
CD3E
Host Species:
Human
Antibody Type:
Monoclonal
Clone ID:
SAA2242
Reactivity:
Human
Buffer:
0.01M PBS pH 7.4.
Storage & Shipping:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
