Anti-Human CD4 Recombinant Monoclonal Antibody (SAA2002) is a recombinant monoclonal antibody targeting Human CD4 (clone SAA2002). It is a human IgG4, kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA and Western blot. Purity: >95% as determined by SDS-PAGE. For research use only.
T-cell surface glycoprotein CD4 is a ~51 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
