Anti-Human CD7 In Vivo Antibody

Product Name:	Anti-Human CD7 In Vivo Antibody - Low Endotoxin
Product Code:	IVMB0123
Size:	1mg, 5mg, 25mg, 50mg, 100mg
Clone:	T3-3A1
Protein:	CD7
Product Type:	Monoclonal Antibody
Isotype:	Mouse IgG1 κ
Reactivity:	Human
Applications:	FC, IF Staining
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:	FC, IF Staining
Recommended Usage:	FC The suggested concentration for this T3-3A1 antibody for staining cells in flow cytometry is ≤ 0.5 - 1 µg per 10⁶ in a volume of 0.1 ml or 0.1 ml of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Reactivity:	Human

Host Species:	Mouse
Specificity:	Clone T3-3A1 recognizes an epitope on human CD7.
Antigen Distribution:	CD7 is expressed on T cells, NK cells, thymocytes, hematopoietic progenitors, some normal B cells, malignant B cells, acute lymphocytic leukemia (ALL) cells, and some acute myeloid leukemia (AML) cells. It is weakly expressed on monocytes.
Concentration:	≥ 2.0 mg/ml
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC >95% by SDS Page
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CD7 is a 40 kD type I transmembrane glycoprotein and is a member of the Ig superfamily. It plays a vital role in T-cell interactions, in adition to, T-cell/B-cell interaction during early lymphoid development, and has been shown to interact with PIK3R1. Functional studies indicate that crosslinking of the CD7 can stimulate transmembrane calcium flux in T cells. Lack of CD7 expression can help to diagnose T-cell lymphoproliferative disorders, such as mycosis fungoides/Sezary syndrome and adult T-cell leukemia/lymphoma.

Technical Datasheet:	View
Protein:	CD7
Ligand/Receptor:	Cytoplasmic domain associates with P13-kinase
Research Area:	Costimulatory Molecules, Immunology

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