Anti-Human CD79α/CD79A Monoclonal Antibody (1A575) is a mouse monoclonal antibody of isotype IgG. Immunogen: E. coli - derived recombinant human CD79α/CD79A (Met35-Gly219). Target: B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A. Species reactivity: Human. Applications: ELISA, IHC, WB. Protein A/G purified from cell culture supernatant. Supplied as a liquid in 0.01M PBS, pH 7.4.
B-cell antigen receptor complex-associated protein alpha chain (CD79α/CD79A) is a ~25 kDa protein. Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases.