Anti-Human CFH Recombinant Nanobody (SAA2038) is a recombinant nanobody targeting Human CFH (clone SAA2038). Format: VHH-8His-Cys-tag (alpaca host). Reactivity: Human. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA. Purity: >95% as determined by SDS-PAGE. For research use only.
Complement factor H (CFH) is a ~139 kDa protein. Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors.
Product Name:
Anti-Human CFH Recombinant Nanobody (SAA2038)
Size:
50 µg, 100 µg, 1 mg
Product SKU:
GXRM03587
Target:
Complement factor H
Host Species:
Alpaca
Antibody Type:
Monoclonal
Clone ID:
SAA2038
Reactivity:
Human
Buffer:
0.01M PBS pH 7.4.
Storage & Shipping:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Format:
Liquid
Applications:
ELISA
Recommended Dilutions:
ELISA: 1:2000-1:20000
Antibody Isotype:
VHH-8His-Cys-tag
Purity:
>95% as determined by SDS-PAGE.
Purification:
Purified by Nickel column.
Endotoxin Level:
< 10 EU/mg
Guarantee:
12 months
UniProt:
P08603
Synonyms:
Complement factor H, CFH, H factor 1, HF1, HF, HF2
