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Anti-MICA Antibody CAB19256
Key Features

MICA Rabbit Monoclonal Antibody (CAB19256)

Datasheet MSDS
SKU CAB19256
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse
Host Species Rabbit
Synonyms MIC-A, PERB11.1, MICA
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

MICA Monoclonal Antibody (CAB19256)

The MICA Monoclonal Antibody (CAB19256) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blotting.MICA, a stress-induced protein, serves as a ligand for the NKG2D receptor on natural killer cells and CD8+ T cells, triggering the immune response against infected or transformed cells.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:MICA Monoclonal Antibody
SKU:CAB19256
Size:20μL, 100μL
Reactivity:Human, Mouse
Clone Number:ARC2422
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:HLDG QPFL RCDR QKCR AKPQ GQWA EDVL GNKT WDRE TRDL TGNG KDLR MTLA HIKD QKEG LHSL QEIR VCEI HEDN STRS SQHF YYDG ELFL SQNL ETKE W
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MIC-A, PERB11.1, MICA
Positive Sample:MCF7, Jurkat, OVCAR3, Mouse stomach
Cellular Localization:Cell Membrane, Cytoplasm, Single-Pass Type I Membrane Protein.
Calculated MW:43kDa
Observed MW:43kDa/60-80kDa

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID100507436
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using MICA Rabbit mAb (CAB19256) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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