Anti-Mouse COMP Recombinant Monoclonal Antibody (15A11) is a recombinant monoclonal antibody targeting Mouse COMP (clone 15A11). It is a mouse IgG1 antibody. Reactivity: Mouse, Rat. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA and immunohistochemistry. Purity: >95% as determined by SDS-PAGE. For research use only.
Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP).
