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Description
Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin
Introducing the Anti-Mouse PD-1 [RMP1-14] In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the programmed cell death protein 1 (PD-1), a key regulator of immune response, making it ideal for research in immunology and related fields. With a rat IgG2a isotype, it ensures high purity and low endotoxin levels (<1.0 EU/mg), perfect for ELISA, flow cytometry, immunohistochemistry, and other assays.
Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. PD-1 is a protein found on the surface of T-cells and pro-B cells. It plays a significant role in the immune system by inhibiting T-cell activity to prevent autoimmune responses. This makes it a crucial target in cancer immunotherapy and autoimmune disease research.
| Product Name: | Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo-Low Endotoxin |
| Product Code: | IVMB0037 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | RMP1-14 |
| Protein: | PD-1 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | Programmed Death-1, CD279, PD 1 |
| Isotype: | Rat IgG2a κ |
| Reactivity: | Mouse |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Applications: | B, FA, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, FA, WB |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Specificity: | Clone RMP1-14 recognizes an epitope on mouse PD-1. |
| Antigen Distribution: | PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
PD-1 is a 50-55 kD member of the B7 Ig superfamily. PD-1 is also a member of the extended CD28/CTLA-4 family of T cell regulators and is suspected to play a role in lymphocyte clonal selection and peripheral tolerance. The ligands of PD-1 are PD-L1 and PD-L2, and are also members of the B7 Ig superfamily. PD-1 and its ligands negatively regulate immune responses. PD-L1, or B7-Homolog 1, is a 40 kD type I transmembrane protein that has been reported to costimulate T cell growth and cytokine production. The interaction of PD-1 with its ligand PD-L1 is critical in the inhibition of T cell responses that include T cell proliferation and cytokine production. PD-L1 has increased expression in several cancers. Inhibition of the interaction between PD-1 and PD-L1 can serve as an immune checkpoint blockade by improving T-cell responses In vitro and mediating preclinical antitumor activity. Within the field of checkpoint inhibition, combination therapy using anti-PD1 in conjunction with anti-CTLA4 has significant therapeutic potential for tumor treatments. PD-L2 is a 25 kD type I transmembrane ligand of PD-1. Via PD-1, PD-L2 can serve as a co-inhibitor of T cell functions. Regulation of T cell responses, including enhanced T cell proliferation and cytokine production, can result from mAbs that block the PD-L2 and PD-1 interaction.
| Datasheet: | View |
| Protein: | PD-1 |
| Function: | Lymphocyte clonal selection, peripheral tolerance |
| Ligand/Receptor: | PD-L1 (B7-H1), PD-L2 |
| Research Area: | Apoptosis, Cancer, Cell Biology, Cell Death, Immunology, Inhibitory Molecules, Tumor Suppressors |
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| Turley et al. | Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity | Cell Reports Medicine 2024 | PubMed ID: 38729159 |
| Charlotte M. Leane et al. | PD-1 regulation of pathogenic IL-17-secreting γδ T cells in experimental autoimmune encephalomyelitis | Eurpeon Journal of Immunology 2024 | PubMed ID: 38996350 |
| Mavroeidi, D., et al. | ATR Blockade Potentiates the Effects of Genotoxic Agents In Vitro and Promotes Antitumor Immunity in a Mouse Model of Non-Small Cell Lung Cancer | Cancers 2026 | View Citation |
| Bedos, M. R., et al. | Targeting cancer-intrinsic protein neddylation bypasses the loss of JAK/STAT signaling and overcomes acquired resistance to immunotherapy | 2026 | View Citation |
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