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Anti-Phospho-TAK1-T187 Antibody (CABP1222)

SKU:
CABP1222
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CSCF
FMD2
MEKK7
TAK1
TGF1a
MAP3K7
Research Area:
Cell Death
€329 - €419
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Description

Product Name:Phospho-TAK1-T187 Rabbit pAb
Product Code:CABP1222
Size:50uL, 100uL
Synonyms:CSCF, FMD2, MEKK7, TAK1, TGF1a, MAP3K7
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding T187 of human MAP3K7.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding T187 of human MAP3K7.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6885
Uniprot:O43318
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein
Calculated MW:53kDa/56kDa/64kDa/67kDa
Observed MW:82KDa
UniProt Protein Function:TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol

Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; I-kappaB phosphorylation; neural tube formation

NCBI Summary:The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:O43318
NCBI GenInfo Identifier:12643557
NCBI Gene ID:6885
NCBI Accession:O43318.1
UniProt Secondary Accession:O43318,O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3 Q9NZ70, B2RE27, E1P523,
UniProt Related Accession:O43318
Molecular Weight:67,196 Da
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 7
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 7
NCBI Official Symbol:MAP3K7  
NCBI Official Synonym Symbols:TAK1; MEKK7; TGF1a  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 7
UniProt Synonym Protein Names:Transforming growth factor-beta-activated kinase 1
Protein Family:Mitogen-activated protein kinase kinase kinase
UniProt Gene Name:MAP3K7  
UniProt Entry Name:M3K7_HUMAN

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