The Anti-PPM1E Antibody (CAB9374) is a highly specific and sensitive tool for research involving the PPM1E protein, also known as protein phosphatase 1E. This antibody, produced in rabbits, is recommended for use in Western blot applications and has been validated for its ability to detect PPM1E in human samples.PPM1E is a phosphatase enzyme that plays a pivotal role in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Dysregulation of PPM1E has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Therefore, studying the expression and function of PPM1E is essential for understanding its role in disease progression and identifying potential therapeutic targets.
By using the Anti-PPM1E Antibody, researchers can accurately measure PPM1E levels in different cell types and tissues, enabling detailed analysis of its biological functions. This antibody is a valuable tool for scientists working in fields such as cell biology, biochemistry, and cancer research, providing insights into the molecular mechanisms underlying disease pathology and offering potential strategies for therapeutic intervention.
Product Name:
PPM1E Monoclonal Antibody
SKU:
CAB9374
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human PPM1E (Q8WY54).
This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
22843
Clone Number:
ARC2763
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using (CAB9374) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
