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Anti-PRKCSH Antibody (CAB0894)

SKU:
CAB0894
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PRKCSH
AGE-R2
G19P1
GIIB
PCLD
PCLD1
PKCSH
PLD1
VASAP-60
glucosidase 2 subunit beta
€139 - €419
Frequently bought together:

Description

Product Name:PRKCSH Rabbit mAb
Product Code:CAB0894
Size:20uL, 50uL, 100uL
Synonyms:PRKCSH, AGE-R2, G19P1, GIIB, PCLD, PCLD1, PKCSH, PLD1, VASAP-60, glucosidase 2 subunit beta
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PRKCSH.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2, A-549, SKOV3
Immunogen:A synthesized peptide derived from human PRKCSH.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5589
Uniprot:P14314
Cellular Location:Endoplasmic reticulum
Calculated MW:80kDa
Observed MW:80KDa
UniProt Protein Function:PRKCSH: Regulatory subunit of glucosidase II. Defects in PRKCSH are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD), which in a considerable but uncertain proportion of cases is associated with hepatic cysts. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; intracellular

Molecular Function:protein kinase C binding; phosphoprotein binding; calcium ion binding

Biological Process: cellular protein metabolic process; protein folding; innate immune response; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification

Disease: Polycystic Liver Disease

NCBI Summary:This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Code:P14314
NCBI GenInfo Identifier:116242499
NCBI Gene ID:5589
NCBI Accession:P14314.2
UniProt Secondary Accession:P14314,Q96BU9, Q96D06, Q9P0W9, A8K318,
UniProt Related Accession:P14314
Molecular Weight:528
NCBI Full Name:Glucosidase 2 subunit beta
NCBI Synonym Full Names:protein kinase C substrate 80K-H
NCBI Official Symbol:PRKCSH  
NCBI Official Synonym Symbols:PCLD; PLD1; G19P1; PKCSH; AGE-R2  
NCBI Protein Information:glucosidase 2 subunit beta; hepatocystin; AGE-binding receptor 2; glucosidase II subunit beta; protein kinase C substrate, 80 Kda protein; protein kinase C substrate 60.1 kDa protein heavy chain
UniProt Protein Name:Glucosidase 2 subunit beta
UniProt Synonym Protein Names:80K-H protein; Glucosidase II subunit beta; Protein kinase C substrate 60.1 kDa protein heavy chain; PKCSH
Protein Family:Glucosidase
UniProt Gene Name:PRKCSH  
UniProt Entry Name:GLU2B_HUMAN

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