Anti-Rat ARC Recombinant Nanobody (E5#) is a recombinant nanobody targeting Rat ARC (clone E5). Format: VHH-Avi-8His-Cys-tag (alpaca host). Reactivity: Rat. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA and neutralization assays. Purity: >95% as determined by SDS-PAGE. For research use only.
Activity-regulated cytoskeleton-associated protein (ARC) is a ~45 kDa protein. Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis.
Product Name:
Anti-Rat ARC Recombinant Nanobody (E5#)
Size:
50 µg, 100 µg, 1 mg
Product SKU:
GXRM04019
Target:
Activity-regulated cytoskeleton-associated protein
Host Species:
Alpaca
Antibody Type:
Monoclonal
Clone ID:
E5#
Reactivity:
Rat
Buffer:
0.01M PBS pH 7.4
Storage & Shipping:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
