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Anti-SERPING1 Antibody (CAB19259)

SKU:
CAB19259
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SERPING1
C1IN
C1INH
C1NH
HAE1
HAE2
serpin family G member 1
Research Area:
Cardiovascular
$167 - $503
Frequently bought together:

Description

Product Name:SERPING1 Rabbit mAb
Product Code:CAB19259
Size:20uL, 50uL, 100uL
Synonyms:SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SERPING1.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant protein of human SERPING1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:710
Uniprot:P05155
Cellular Location:Secreted
Calculated MW:100kDa
Observed MW:Refer to figures
UniProt Protein Function:SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

NCBI Summary:This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Code:P05155
NCBI GenInfo Identifier:124096
NCBI Gene ID:710
NCBI Accession:P05155.2
UniProt Secondary Accession:P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2,
UniProt Related Accession:P05155
Molecular Weight:
NCBI Full Name:Plasma protease C1 inhibitor
NCBI Synonym Full Names:serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol:SERPING1  
NCBI Official Synonym Symbols:C1IN; C1NH; HAE1; HAE2; C1INH  
NCBI Protein Information:plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name:Plasma protease C1 inhibitor
UniProt Synonym Protein Names:C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family:Para-Rep
UniProt Gene Name:SERPING1  
UniProt Entry Name:IC1_HUMAN

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