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Anti-TACSTD2 Antibody (CAB8129)

SKU:
CAB8129
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TACSTD2
EGP-1
EGP1
GA733-1
GA7331
GP50
M1S1
TROP2
€139 - €419
Frequently bought together:

Description

Product Name:TACSTD2 Rabbit pAb
Product Code:CAB8129
Size:20uL, 50uL, 100uL
Synonyms:TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-270 of human TACSTD2 (NP_002344.2).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, A-431, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-270 of human TACSTD2 (NP_002344.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HTAA QDNC TCPT NKMT VCSP DGPG GRCQ CRAL GSGM AVDC STLT SKCL LLKA RMSA PKNA RTLV RPSE HALV DNDG LYDP DCDP EGRF KARQ CNQT SVCW CVNS VGVR RTDK GDLS LRCD ELVR THHI LIDL RHRP TAGA FNHS DLDA ELRR LFRE RYRL HPKF VAAV HYEQ PTIQ IELR QNTS QKAA GDVD IGDA AYYF ERDI KGES LFQG RGGL DLRV RGEP LQVE RTLI YYLD EIPP KFSM
Gene ID:4070
Uniprot:P09758
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:35kDa
Observed MW:37-50KDa
UniProt Protein Function:TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: basal plasma membrane; cytosol; extracellular space; integral to plasma membrane; lateral plasma membrane; membrane; nucleus

Molecular Function:protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation

Disease: Corneal Dystrophy, Gelatinous Drop-like

NCBI Summary:This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
UniProt Code:P09758
NCBI GenInfo Identifier:160113102
NCBI Gene ID:4070
NCBI Accession:P09758.3
UniProt Secondary Accession:P09758,Q15658, Q6FG48, Q7Z7Q4, Q96QD2,
UniProt Related Accession:P09758
Molecular Weight:35,709 Da
NCBI Full Name:Tumor-associated calcium signal transducer 2
NCBI Synonym Full Names:tumor-associated calcium signal transducer 2
NCBI Official Symbol:TACSTD2  
NCBI Official Synonym Symbols:EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1  
NCBI Protein Information:tumor-associated calcium signal transducer 2
UniProt Protein Name:Tumor-associated calcium signal transducer 2
UniProt Synonym Protein Names:Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
Protein Family:Tumor-associated calcium signal transducer
UniProt Gene Name:TACSTD2  
UniProt Entry Name:TACD2_HUMAN

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