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Anti-Tbx3 Antibody (CAB9646)

SKU:
CAB9646
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TBX3-ISO
UMS
XHL
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:Tbx3 Rabbit mAb
Product Code:CAB9646
Size:20uL, 50uL, 100uL
Synonyms:TBX3-ISO, UMS, XHL
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Tbx3
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Rat liver
Immunogen:A synthesized peptide derived from human Tbx3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6926
Uniprot:O15119
Calculated MW:85kDa
Observed MW:80KDa
UniProt Protein Function:TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: nucleus

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Ulnar-mammary Syndrome

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O15119
NCBI GenInfo Identifier:28381401
NCBI Gene ID:6926
NCBI Accession:O15119.4
UniProt Secondary Accession:O15119,Q8TB20, Q9UKF8,
UniProt Related Accession:O15119
Molecular Weight:743
NCBI Full Name:T-box transcription factor TBX3
NCBI Synonym Full Names:T-box 3
NCBI Official Symbol:TBX3  
NCBI Official Synonym Symbols:UMS; XHL; TBX3-ISO  
NCBI Protein Information:T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL
UniProt Protein Name:T-box transcription factor TBX3
Protein Family:T-box transcription factor
UniProt Gene Name:TBX3  
UniProt Entry Name:TBX3_HUMAN

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