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Anti-TBX3 Antibody (CAB4144)

SKU:
CAB4144
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

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Antibody Name:Anti-TBX3 Antibody
Antibody SKU:CAB4144
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-385 of human TBX3 (NP_057653.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:BT-474, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-385 of human TBX3 (NP_057653.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HKYQ PRFH IVRA NDIL KLPY STFR TYLF PETE FIAV TAYQ NDKI TQLK IDNN PFAK GFRD TGNG RREK RKQL TLQS MRVF DERH KKEN GTSD ESSS EQAA FNCF AQAS SPAA STVG TSNL KDLC PSEG ESDA EAES KEEH
Gene ID:6926
Uniprot:O15119
Cellular Location:Nucleus
Calculated MW:65kDa/77kDa/79kDa
Observed MW:79kDa
Synonyms:TBX3, TBX3-ISO, UMS, XHL, T-box 3
Background:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
UniProt Protein Function:TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.21

Cellular Component: nucleus

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Ulnar-mammary Syndrome

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O15119
NCBI GenInfo Identifier:28381401
NCBI Gene ID:6926
NCBI Accession:O15119.4
UniProt Secondary Accession:O15119,Q8TB20, Q9UKF8,
UniProt Related Accession:O15119
Molecular Weight:743
NCBI Full Name:T-box transcription factor TBX3
NCBI Synonym Full Names:T-box 3
NCBI Official Symbol:TBX3  
NCBI Official Synonym Symbols:UMS; XHL; TBX3-ISO  
NCBI Protein Information:T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL
UniProt Protein Name:T-box transcription factor TBX3
Protein Family:T-box transcription factor
UniProt Gene Name:TBX3  
UniProt Entry Name:TBX3_HUMAN
Anti-TBX3 Antibody (CAB4144)Western blot analysis of extracts of various cell lines, using TBX3 antibody (CAB4144) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).

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