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Anti-TFE3 Antibody (CAB7936)

SKU:
CAB7936
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TFE3
RCCP2
RCCX1
TFEA
bHLHe33
$167 - $503
Frequently bought together:

Description

Product Name:TFE3 Rabbit pAb
Product Code:CAB7936
Size:20uL, 50uL, 100uL
Synonyms:TFE3, RCCP2, RCCX1, TFEA, bHLHe33
Applications:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFE3 (NP_006512.2).
Applications:IF
Recommended Dilutions:IF 1:50 - 1:200
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFE3 (NP_006512.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSHA AEPA RDGV EASA EGPR AVFV LLEE RRPA DSAQ LLSL NSLL PESG IVAD IELE NVLD PDSF YELK SQPL PLRS SLPI SLQA TPAT PATL SASS SAGG SRTP AMSS SSSS RVLL RQQL MRAQ AQEQ ERRE RREQ AAAA PFPS PAPA SPAI SVVG VSAG
Gene ID:7030
Uniprot:P19532
Cellular Location:Nucleus
Calculated MW:11kDa/61kDa
Observed MW:Refer to figures
UniProt Protein Function:TFE3: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. A chromosomal aberration involving TFE3 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with ASPSCR1 forms a ASPSCR1-TFE3 fusion protein. Chromosomal aberrations involving TFE3 are found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with PRCC; translocation t(X;1)(p11.2;p34) with PSF; inversion inv(X)(p11.2;q12) that fuses NONO to TFE3. Belongs to the MiT/TFE family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein dimerization activity; transcription factor activity

Biological Process: positive regulation of cell adhesion; regulation of osteoclast differentiation; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; humoral immune response

Disease: Renal Cell Carcinoma, Xp11-associated

NCBI Summary:This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Code:P19532
NCBI GenInfo Identifier:160113240
NCBI Gene ID:7030
NCBI Accession:P19532.4
UniProt Secondary Accession:P19532,Q5JU74, Q92757, Q92758, Q99964, A8MZL6,
UniProt Related Accession:P19532
Molecular Weight:575
NCBI Full Name:Transcription factor E3
NCBI Synonym Full Names:transcription factor binding to IGHM enhancer 3
NCBI Official Symbol:TFE3  
NCBI Official Synonym Symbols:TFEA; RCCP2; RCCX1; bHLHe33  
NCBI Protein Information:transcription factor E3; transcription factor for IgH enhancer; transcription factor E family, member A; class E basic helix-loop-helix protein 33; transcription factor for immunoglobulin heavy-chain enhancer 3
UniProt Protein Name:Transcription factor E3
UniProt Synonym Protein Names:Class E basic helix-loop-helix protein 33; bHLHe33
Protein Family:Transcription factor
UniProt Gene Name:TFE3  
UniProt Entry Name:TFE3_HUMAN

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