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Anti-TSC2 Antibody (CAB0491)

SKU:
CAB0491
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LAM
PPP1R160
TSC4
TSC2
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:TSC2 Rabbit pAb
Product Code:CAB0491
Size:100uL
Synonyms:LAM, PPP1R160, TSC4, TSC2, Tuberin, tuberin
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human TSC2
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:200 - 1:500 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse brain
Immunogen:A synthetic peptide of human TSC2
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7249
Uniprot:P49815
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:25kDa/187-200kDa
Observed MW:200KDa
UniProt Protein Function:TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; TSC1-TSC2 complex

Molecular Function:GTPase activator activity; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding

Biological Process: anoikis; cell cycle arrest; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of Wnt receptor signaling pathway; neural tube closure; positive chemotaxis; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling cascade; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; vesicle-mediated transport

Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 2

NCBI Summary:Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P49815
NCBI GenInfo Identifier:269849475
NCBI Gene ID:7249
NCBI Accession:P49815.2
UniProt Secondary Accession:P49815,O75275, Q4LE71, Q8TAZ1, A7E2E2, B4DIL8, B4DIQ7 B4DRN2, B7Z2B8, C9J378,
UniProt Related Accession:P49815
Molecular Weight:25,773 Da
NCBI Full Name:Tuberin
NCBI Synonym Full Names:tuberous sclerosis 2
NCBI Official Symbol:TSC2  
NCBI Official Synonym Symbols:LAM; TSC4; PPP1R160  
NCBI Protein Information:tuberin
UniProt Protein Name:Tuberin
UniProt Synonym Protein Names:Tuberous sclerosis 2 protein
Protein Family:Tuberin
UniProt Gene Name:TSC2  

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