Description

APC Anti-Mouse CD51 Antibody [RMV-7]

The Mouse Anti-Mouse CD51 Antibody (RMV-7) is a powerful tool for researchers studying cell adhesion and migration processes. CD51, also known as Integrin Alpha V, is a key protein involved in cell interactions with the extracellular matrix and other cells, playing a critical role in various physiological and pathological processes.This antibody, specifically designed for mouse samples, is highly specific and has been rigorously validated for use in various experimental applications, including immunohistochemistry and flow cytometry. Its ability to bind to CD51 with high affinity allows for precise detection and analysis of this important cell surface marker in a wide range of experimental systems.

Understanding the function and regulation of CD51 is essential for unraveling its roles in processes such as tissue development, angiogenesis, and cancer metastasis. Researchers interested in investigating cell adhesion dynamics, angiogenesis-related pathways, or the role of integrins in disease progression will find the Mouse Anti-Mouse CD51 Antibody (RMV-7) to be a valuable asset in their studies.

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Product Title:	APC Anti-Mouse CD51 Antibody [RMV-7]
SKU:	AGEL2725
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	RMV-7
Synonyms:	Integrin alpha-V;αV integrin;Vitronectin Receptor;Integrin αV chain;ITGAV;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG1, κ
Isotype Control:	APC Rat IgG1, κ Isotype Control[HRPN]
Form:	Liquid
Conjugation:	APC
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P43406
Gene ID:	16410
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

APC Anti-Mouse CD51 Antibody [RMV-7] (AGEL2725)

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Description