Description

APC Anti-Mouse CD62L Antibody [Mel14]

The APC Anti-Mouse CD62L Antibody (MEL-14) available at assaygenie.com is a vital tool for researchers studying immune responses in mice. This antibody specifically targets CD62L, a cell surface molecule crucial for lymphocyte migration and homing to secondary lymphoid organs. By binding to CD62L, the antibody enables precise detection and analysis of this key protein in various cell types, making it an invaluable asset in immunology research.CD62L, also known as L-selectin, plays a pivotal role in immune cell trafficking and activation, facilitating interactions between lymphocytes and endothelial cells during inflammatory responses. Understanding the expression and function of CD62L is essential for unraveling the complexities of immune cell behavior in health and disease, particularly in conditions such as inflammation, infection, and autoimmune disorders.

With its high specificity and reliability, the APC Anti-Mouse CD62L Antibody (MEL-14) offers researchers a powerful tool to investigate the intricate mechanisms governing immune cell movement and activation in mouse models. Whether studying immune responses in infectious diseases, autoimmune conditions, or cancer, this antibody provides accurate and reproducible results, driving advancements in our understanding of immune system regulation and therapeutic development.

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Product Title:	APC Anti-Mouse CD62L Antibody [Mel14]
SKU:	AGEL2146
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	Mel14
Synonyms:	L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	APC Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	APC
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P18337
Gene ID:	20343
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

APC Anti-Mouse CD62L Antibody [Mel14] (AGEL2146)

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Description