Anti-AQP4 Antibody (PACO17747)

Antibody Name:	AQP4 Antibody (PACO17747)
Antibody SKU:	PACO17747
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human AQP4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17747(AQP4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO17747(AQP4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17747(AQP4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms:	aquaporin 4

UniProt Protein Function:	AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described
UniProt Protein Details:	Protein type:Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 18q11.2-q12.1 Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane Molecular Function:glycerol channel activity; water channel activity; water transporter activity Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport
NCBI Summary:	This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Code:	P55087
NCBI GenInfo Identifier:	2506859
NCBI Gene ID:	361
NCBI Accession:	P55087.2
UniProt Secondary Accession:	P55087,P78564,
UniProt Related Accession:	P55087
Molecular Weight:	32,300 Da
NCBI Full Name:	Aquaporin-4
NCBI Synonym Full Names:	aquaporin 4
NCBI Official Symbol:	AQP4
NCBI Official Synonym Symbols:	MIWC; WCH4
NCBI Protein Information:	aquaporin-4
UniProt Protein Name:	Aquaporin-4
UniProt Synonym Protein Names:	Mercurial-insensitive water channel; MIWC; WCH4
Protein Family:	Aquaporin
UniProt Gene Name:	AQP4
UniProt Entry Name:	AQP4_HUMAN

Antibodies	ELISA Kits
Anti-Aquaporin 4 Antibody (CAB13926)	Human AQP4 / Aquaporin-4 ELISA Kit
Anti-Aquaporin 4 Antibody (CAB2887)	Human AQP-4 (Aquaporin 4) CLIA Kit (HUES00352)
Anti-AQP4 Antibody (CAB11210)	Human AQP-4 (Aquaporin 4) ELISA Kit (HUES01694)
Anti-Aquaporin 4 Antibody (CAB5665)	Human Aquaporin-4 (AQP4) ELISA Kit
AQP4 Antibody (PACO00414)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)