Ascrinvacumab Antibody is a research-grade biosimilar monoclonal antibody targeting Serine/threonine-protein kinase receptor R3. It is a human IgG2-kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, Western blot, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Product Name:
Ascrinvacumab Antibody
SKU:
GXBS00450
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Serine/threonine-protein kinase receptor R3
Isotype:
IgG2-kappa
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, WB, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
PF-03446962, 1463459-96-2
Recommended Dilutions:
ELISA: 1:2000-1:20000; WB: 1:500-1:2000
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
