null

ATM Rabbit Monoclonal Antibody (CAB19650)

SKU:
CAB19650
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ATM Rabbit Monoclonal Antibody
SKU:CAB19650
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2619-2939 of human ATM (Q13315).
Sequence:SVEA LCDA YIIL ANLD ATQW KTQR KGIN IPAD QPIT KLKN LEDV VVPT MEIK VDHT GEYG NLVT IQSF KAEF RLAG GVNL PKII DCVG SDGK ERRQ LVKG RDDL RQDA VMQQ VFQM CNTL LQRN TETR KRKL TICT YKVV PLSQ RSGV LEWC TGTV PIGE FLVN NEDG AHKR YRPN DFSA FQCQ KKMM EVQK KSFE EKYE VFMD VCQN FQPV FRYF CMEK FLDP AIWF EKRL AYTR SVAT SSIV GYIL GLGD RHVQ NILI NEQS AELV HIDL GVAF EQGK ILPT PETV PFRL TRDI VDGM GITG VEGV FRRC CEKT MEVM R
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; ATM
Positive Sample:Raji,HepG2,HeLa,293T,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Cytoplasmic vesicle, Nucleus.
Calculated MW:351kDa
Observed MW:350kDa

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Purification Method:Affinity purification
Gene ID:472
Clone Number:ARC0129
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ATM Rabbit mAb (CAB19650) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

Related Products