The ATRIP Polyclonal Antibody (CAB7139) is a key tool for researchers studying the ATRIP protein, a crucial component of the DNA damage response pathway. This antibody was raised in rabbits and exhibits high reactivity with human samples, making it an excellent choice for Western blot applications. By binding specifically to the ATRIP protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in DNA repair, cell cycle regulation, and cancer research.ATRIP is a well-known sensor protein that plays a central role in activating the ATR kinase pathway in response to DNA damage.
Dysfunction in the ATRIP protein is associated with various human diseases, including cancer and genetic disorders. By understanding the function and regulation of ATRIP, researchers can uncover new insights into disease mechanisms and potential therapeutic strategies targeting the DNA damage response pathway. The ATRIP Polyclonal Antibody is a valuable tool for advancing research in these fields.
Product Name:
ATRIP Rabbit Polyclonal Antibody
SKU:
CAB7139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ATRIP (NP_569055.1).
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
84126
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATRIP antibody (CAB7139) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
