ATRIP
ATRIP (ATR-interacting protein) is a nuclear protein that is essential for DNA damage checkpoint signalling. It partners with the ataxia telangiectasia and Rad3 related protein kinase and is also known by the aliases FLJ12343, MGC20625, MGC21482 and MGC26740. Browse Assay Genie's current range of ATRIP research reagents below, or read on for the biology behind the target.
ATRIP is required for checkpoint signalling after DNA damage. The protein binds to single-stranded DNA coated with replication protein A, and it also interacts with the ataxia telangiectasia and Rad3 related (ATR) protein kinase. This interaction results in the accumulation of ATR at intranuclear foci induced by DNA damage. ATRIP is also required for ATR expression, possibly by stabilising the ATR protein.
The human ATRIP gene encodes an essential component of the DNA damage checkpoint. The ATRIP protein is localised to the nucleus and belongs to the ATRIP family. HGNC classifies it within the armadillo like helical domain containing gene group. Multiple transcript variants encoding different isoforms have been reported for this gene. The mouse ortholog is named Atrip.
The gene is listed under the approved name ATR interacting protein, with the aliases FLJ12343, MGC20625, MGC21482 and MGC26740. Because of its role in coupling ATR to sites of DNA damage, ATRIP is a common subject in studies of checkpoint signalling and the cellular response to damaged or replicating DNA. Researchers investigating ATRIP protein levels, the ATRIP gene or its relationship with ATR and replication protein A will find it relevant to work on genome maintenance.
ATRIP is required for checkpoint signalling after DNA damage, making it a key component for studying how cells respond to genotoxic stress.
ATRIP interacts with ATR and is required for ATR expression, possibly by stabilising the protein, so it is central to ATR function studies.
ATRIP binds single-stranded DNA coated with replication protein A, linking checkpoint signalling to exposed DNA at damage sites.
ATR accumulates at intranuclear foci induced by DNA damage through its interaction with ATRIP, a feature used to follow checkpoint activation.
ATRIP is required for checkpoint signalling after DNA damage. It binds single-stranded DNA coated with replication protein A and interacts with ATR kinase, leading to ATR accumulation at DNA damage-induced nuclear foci. It is also required for ATR expression, possibly by stabilising it.
ATRIP stands for ATR-interacting protein, and HGNC lists the name as ATR interacting protein. Aliases include FLJ12343, MGC20625, MGC21482 and MGC26740. Multiple transcript variants encoding different isoforms have been found for the gene.
The mouse has an ortholog named Atrip, which allows the protein's role in checkpoint signalling to be studied in rodent models. Check the datasheet of any product for its validated reactivity.
Other DNA damage checkpoint proteins, ATR pathway partners and replication stress markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WXE1; product specifications from Assay Genie datasheets.