MAPK13
MAPK13 (mitogen-activated protein kinase 13, also known as SAPK4, p38delta or PRKM13) is a serine/threonine kinase of the p38 MAP kinase family. It relays signals from pro-inflammatory cytokines and cellular stress to transcription factors and downstream kinases. Browse Assay Genie's current range of MAPK13 research reagents below, or read on for the biology behind the target.
MAPK13 is a serine/threonine kinase and an essential component of the MAP kinase signal transduction pathway. It is one of the four p38 MAPKs, which mediate cellular responses to extracellular stimuli such as pro-inflammatory cytokines and physical stress. Activation of these kinases leads to direct activation of transcription factors including ELK1 and ATF2. p38 MAPKs phosphorylate a broad range of proteins, and each has been estimated to have approximately 200 to 300 substrates. Some of these are downstream kinases, such as MAPKAPK2, which are activated by phosphorylation and in turn phosphorylate further targets.
Reported substrates and roles of MAPK13 are varied. It regulates protein translation by phosphorylating and inactivating EEF2K, and it contributes to cytoskeletal remodelling through phosphorylation of MAPT and stathmin (STMN1). It mediates UV-induced up-regulation of CXCL14 expression, and phosphorylates the transcriptional activator MYB in response to stress, leading to rapid proteasome-dependent MYB degradation. In pancreatic beta cells, MAPK13 phosphorylates and down-regulates PRKD1 during the regulation of insulin secretion. It also plays an important role in epidermal keratinocyte differentiation, apoptosis and skin tumour development.
The MAPK13 gene belongs to the HGNC mitogen-activated protein kinase 11-14 (p38) family, and the protein sits in the CMGC Ser/Thr protein kinase superfamily, MAP kinase subfamily. MAP kinases act as an integration point for multiple biochemical signals and are involved in proliferation, differentiation, transcription regulation and development. MAPK13 is one of the less studied p38 isoforms, and alternatively spliced transcript variants have been observed for the gene. Mouse and rat each have a Mapk13 ortholog.
MAPK13 is activated by pro-inflammatory cytokines and cellular stress, making it relevant to studies of p38 MAPK cascades.
MAPK13 regulates epidermal keratinocyte differentiation, apoptosis and skin tumour development, and mediates UV-induced CXCL14 expression.
MAPK13 phosphorylates and down-regulates PRKD1 during the regulation of insulin secretion in pancreatic beta cells.
Substrates such as EEF2K, MAPT and STMN1 link MAPK13 to protein translation and cytoskeletal remodelling.
MAPK13 is a serine/threonine kinase in the MAP kinase pathway. Activated by cytokines and stress, it phosphorylates transcription factors such as ELK1, ATF2 and MYB, and other substrates including EEF2K, MAPT, STMN1 and PRKD1, affecting translation, cytoskeleton, differentiation and insulin secretion.
MAPK13 is also called SAPK4, p38delta and PRKM13. It is one of four p38 MAPKs, alongside MAPK11, MAPK12 and MAPK14. The gene has alternatively spliced transcript variants, so check the datasheet of any product for its validated reactivity and target region.
Yes. Mouse and rat both have an ortholog named Mapk13, so the gene can be studied in rodent models. Human MAPK13 is a less studied p38 isoform, and its role in skin tumour development is among its reported functions.
Other p38 MAP kinase family members, MAPK-activated protein kinases and related MAP kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15264; product specifications from Assay Genie datasheets.