beta-Actin
FLNB (filamin B, also known as TAP, TABP, ABP-278, FH1, FLN1L and LRS1) is an actin-binding protein of the filamin family. It connects cell membrane constituents to the actin cytoskeleton and is linked to several skeletal dysplasias. Browse Assay Genie's current range of beta-Actin research reagents below, or read on for the biology behind the target.
Filamin B is a cytoskeletal scaffold that connects cell membrane constituents to the actin cytoskeleton. It links actin filaments to membrane glycoproteins, anchors various transmembrane proteins to the actin network, and may promote orthogonal branching of actin filaments. Its interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Interactions and localisations of its isoforms affect myotube morphology and myogenesis, and isoform 6 accelerates muscle differentiation in vitro.
The FLNB gene encodes a member of the filamin family, and the protein is annotated in the cytoplasm at the cell cortex, on the cytoskeleton and stress fibres, and at the Z line of the sarcomere. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha and binds the actin cytoskeleton. Multiple alternatively spliced transcript variants encode different protein isoforms. The mouse ortholog is Flnb.
Mutations in FLNB have been found in several conditions: atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome and spondylocarpotarsal synostosis syndrome. The aliases reflect the protein's history. HGNC previously listed it as filamin B, beta (actin binding protein 278) and as Larsen syndrome 1 (autosomal dominant). Researchers studying the FLNB gene or filamin B protein typically work on actin organisation, membrane anchoring and skeletal development.
Filamin B links actin filaments to membrane glycoproteins and may promote orthogonal filament branching, making it relevant to cytoskeletal architecture.
FLNB mutations are found in atelosteogenesis types 1 and 3, boomerang dysplasia, Larsen syndrome and spondylocarpotarsal synostosis syndrome.
Filamin B isoforms influence myotube morphology and myogenesis, and isoform 6 accelerates muscle differentiation in vitro.
Interaction with FLNA may support neuroblast migration, and filamin B interacts with glycoprotein Ib alpha during repair of vascular injuries.
Filamin B connects cell membrane constituents to the actin cytoskeleton. It links actin filaments to membrane glycoproteins, anchors transmembrane proteins to the actin network and may promote orthogonal branching of filaments. It also interacts with glycoprotein Ib alpha during vascular injury repair.
Aliases include TAP, TABP, ABP-278, FH1, FLN1L and LRS1. Earlier HGNC names were filamin B, beta (actin binding protein 278) and Larsen syndrome 1 (autosomal dominant). Multiple spliced transcript variants encode different isoforms, and isoform 6 accelerates muscle differentiation in vitro.
FLNB mutations have been found in atelosteogenesis types 1 and 3, boomerang dysplasia, autosomal dominant Larsen syndrome and spondylocarpotarsal synostosis syndrome. The mouse ortholog is Flnb. Check the datasheet of any product for its validated reactivity.
Other filamin family members, actin cytoskeleton proteins and platelet glycoprotein partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75369; product specifications from Assay Genie datasheets.