EPHX4
EPHX4 (epoxide hydrolase 4) is a membrane-associated member of the epoxide hydrolase family within the AB hydrolase superfamily. It is also known as EPHXRP, EH4 and ABHD7, and is predicted to have hydrolase activity. Browse Assay Genie's current range of EPHX4 research reagents below, or read on for the biology behind the target.
EPHX4 belongs to the epoxide hydrolase family, part of the AB hydrolase superfamily. Its function has not been characterised in detail, and the available gene summary describes it as predicted to enable hydrolase activity and predicted to be located in the membrane. The partial EC classification 3.3.-.- places it among enzymes that act on ether bonds, consistent with the hydrolytic activity of its family. Researchers studying the EPHX4 protein should therefore treat its substrates and physiological role as open questions.
The EPHX4 gene is located on human chromosome 1 and encodes a protein annotated in UniProt under the name epoxide hydrolase 4. HGNC places it in the abhydrolase domain containing gene group. The mouse counterpart is named Ephx4, which allows comparative work in a murine model. No tissue expression pattern or interaction partners are specified in the sources used here, so none are described.
The gene has carried several names. It was previously designated abhydrolase domain containing 7 (ABHD7), and other aliases include EPHXRP, EH4 and FLJ90341. These names reflect its dual identity as an abhydrolase-domain protein and as a relative of the better-known epoxide hydrolases. Related family members such as EPHX1, EPHX2 and EPHX3 are useful reference points when planning experiments, although conclusions about shared function should not be assumed without direct evidence. When searching the literature, it helps to include both the current symbol and the earlier ABHD7 designation, and an EPHX4 antibody or EPHX4 ELISA kit workflow should be designed with that naming overlap in mind.
EPHX4 is a family member of the epoxide hydrolases, making it a candidate for comparative studies alongside EPHX1, EPHX2 and EPHX3.
Its predicted hydrolase activity and partial EC class 3.3.-.- make EPHX4 a subject for work defining its enzymatic role.
EPHX4 is predicted to be located in the membrane, so subcellular localisation studies can help confirm where it acts.
As a former ABHD7 member of the abhydrolase domain containing group, EPHX4 supports studies across AB hydrolase superfamily proteins.
The function of EPHX4 is not fully characterised. It belongs to the epoxide hydrolase family of the AB hydrolase superfamily, and the NCBI Gene summary describes it as predicted to enable hydrolase activity and to be located in the membrane.
EPHX4 is also called EPHXRP, FLJ90341, EH4 and ABHD7. Its previous HGNC name was abhydrolase domain containing 7. The current name, epoxide hydrolase 4, reflects its place in the epoxide hydrolase family.
A mouse ortholog, Ephx4, is recognised, supporting comparative studies in mouse. No rat ortholog is given in the data used here. Check the datasheet of any product for its validated reactivity.
Other epoxide hydrolase family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IUS5; product specifications from Assay Genie datasheets.