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DTX3
DTX3 (deltex E3 ubiquitin ligase 3, also known as RNF154 and FLJ34766) is a RING finger E3 ubiquitin ligase of the Deltex family. It has been linked to degradation of the angiogenic receptor kinase EPHB4 in cancer cells. Browse Assay Genie's current range of DTX3 research reagents below, or read on for the biology behind the target.
DTX3 functions as an E3 ubiquitin ligase, the class of enzyme that confers substrate specificity on the ubiquitin conjugation cascade. The enzyme activity is classified as EC 2.3.2.27, a RING-type E3 ubiquitin transferase. According to UniProt, DTX3 is involved in the degradation of the angiogenic kinase EPHB4 in cancer cells, which places it in the study of ubiquitin-dependent control of receptor tyrosine kinase levels.
The human DTX3 gene encodes a protein recorded in UniProt as E3 ubiquitin-protein ligase DTX3. It belongs to the Deltex family, and HGNC places it within the ring finger proteins and the Deltex E3 ubiquitin ligase family. DTX1 is another member of this family. UniProt lists the protein in both the cytoplasm and the nucleus. The mouse ortholog is Dtx3, which is relevant when planning work in murine models.
The gene has gone by several names. Earlier HGNC names were deltex 3 homolog (Drosophila) and deltex homolog 3 (Drosophila), which reflect its relationship to the Drosophila Deltex gene. Aliases include RNF154 and FLJ34766. The E3 ligase function of DTX3 was reported by Takeyama and colleagues in 2003, as cited in the NCBI Gene summary. Researchers studying DTX3 gene regulation, DTX3 protein levels or ubiquitination pathways in cancer biology can use this background when designing experiments.
DTX3 is an E3 ubiquitin ligase, so it is a candidate for studies of substrate selection and ubiquitin transfer in the Deltex family.
UniProt links DTX3 to degradation of the angiogenic kinase EPHB4 in cancer cells, relevant to receptor turnover research.
Because DTX3 is involved in EPHB4 degradation, it is of interest in work on kinase regulation connected to angiogenesis.
As a Deltex family member related to DTX1, DTX3 supports comparative studies of RING finger E3 ligases.
DTX3 functions as an E3 ubiquitin ligase, as reported by Takeyama and colleagues in 2003. UniProt annotates it as involved in the degradation of the angiogenic kinase EPHB4 in cancer cells. It is found in the cytoplasm and the nucleus.
DTX3 is also known as RNF154 and FLJ34766. Its earlier HGNC names were deltex 3 homolog (Drosophila) and deltex homolog 3 (Drosophila). UniProt names the protein E3 ubiquitin-protein ligase DTX3, and its enzyme classification is EC 2.3.2.27.
A mouse ortholog, Dtx3, is recorded for the human gene. The name also reflects homology to the Drosophila Deltex gene. DTX3 belongs to the Deltex family, which includes DTX1. Check the datasheet of any product for its validated reactivity.
Other Deltex family E3 ubiquitin ligases and related ubiquitin pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N9I9; product specifications from Assay Genie datasheets.
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