SRSF9
SRSF9 (serine and arginine rich splicing factor 9, also known as SRp30c or SFRS9) is a nuclear member of the SR family of pre-mRNA splicing factors. It contributes to constitutive splicing and can modulate the choice of alternative splice sites. Browse Assay Genie's current range of SRSF9 research reagents below, or read on for the biology behind the target.
SRSF9 plays a role in constitutive splicing and can modulate the selection of alternative splice sites. It is also reported to repress the splicing of MAPT/Tau exon 10. As a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, it forms part of the spliceosome, the machinery that removes introns from pre-mRNA.
Like other SR proteins, the SRSF9 protein contains an RNA recognition motif (RRM) that binds RNA and an RS domain, rich in serine and arginine residues, that binds other proteins. The RS domain facilitates interaction between different SR splicing factors. UniProt places the protein in the nucleus, and it belongs to the splicing factor SR family. Beyond splicing, SR proteins have also been shown to take part in mRNA export from the nucleus and in translation.
The SRSF9 gene is classed by HGNC within the RNA binding motif containing group and the serine and arginine rich splicing factors group. It was previously named splicing factor, arginine/serine-rich 9 (symbol SFRS9), and the protein is also called SRp30c. Two pseudogenes of the gene, one on chromosome 15 and one on chromosome 21, have been described. Mouse and rat both have an ortholog named Srsf9, so the target can be studied in common rodent models.
SRSF9 can modulate the selection of alternative splice sites, making it a useful factor for studying how splice site choice is controlled.
As an SR family member with an RRM and an RS domain, SRSF9 helps to define how SR proteins bind RNA and each other.
SRSF9 represses the splicing of MAPT/Tau exon 10, linking this splicing factor to the regulation of a specific transcript.
SR proteins have been shown to act in mRNA export from the nucleus and in translation, extending their roles beyond splicing.
SRSF9 plays a role in constitutive splicing and can modulate the selection of alternative splice sites. It represses the splicing of MAPT/Tau exon 10. As an SR protein it is part of the spliceosome, and SR proteins also contribute to mRNA export and translation.
SRSF9 is also known as SRp30c and by the previous symbol SFRS9. Earlier names include splicing factor, arginine/serine-rich 9 and serine/arginine-rich splicing factor 9. HGNC lists the current name as serine and arginine rich splicing factor 9.
Yes. Mouse and rat each have an ortholog called Srsf9, so the target can be studied in rodent systems. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Other members of the serine and arginine rich splicing factor family involved in pre-mRNA splicing.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13242; product specifications from Assay Genie datasheets.