TSC22D1
TSC22D1 (TSC22 domain family member 1) is a leucine zipper transcription factor of the TSC-22/Dip/Bun family, also known as TSC22 and TGFB1I4. It is stimulated by transforming growth factor beta and has been linked to apoptosis in cancer cells. Browse Assay Genie's current range of TSC22D1 research reagents below, or read on for the biology behind the target.
TSC22D1 is a member of the TSC22 domain family of leucine zipper transcription factors. Its expression is stimulated by transforming growth factor beta, and it regulates the transcription of multiple genes, including C-type natriuretic peptide. UniProt annotates it as a positive regulator of cell death in response to TGFB3 during mammary gland involution.
The TSC22D1 gene encodes a protein of the TSC-22/Dip/Bun family. UniProt records the protein in the cytoplasm, nucleus, cell membrane and mitochondrion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Orthologs are annotated in mouse and rat, both named Tsc22d1.
The official name was formerly written as transforming growth factor beta 1 induced transcript 4, which explains the alias TGFB1I4; other aliases include TSC22 and MGC17597. The encoded protein may play a critical role in tumour suppression through the induction of cancer cell apoptosis. A single nucleotide polymorphism in the promoter of the gene has also been associated with diabetic nephropathy. Researchers studying TSC22D1 therefore work across TGF-beta signalling, cell death regulation and renal disease.
TSC22D1 is stimulated by transforming growth factor beta, making it a useful readout of downstream transcriptional responses.
The protein may contribute to tumour suppression by inducing apoptosis in cancer cells.
TSC22D1 positively regulates cell death in response to TGFB3 during mammary gland involution.
A promoter polymorphism in the TSC22D1 gene has been associated with diabetic nephropathy.
TSC22D1 is a leucine zipper transcription factor stimulated by transforming growth factor beta. It regulates transcription of several genes, including C-type natriuretic peptide, and positively regulates cell death in response to TGFB3 during mammary gland involution. It may also induce apoptosis in cancer cells.
TSC22D1 is also known as TSC22, MGC17597 and TGFB1I4. The last reflects the earlier name, transforming growth factor beta 1 induced transcript 4. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the gene.
Orthologs named Tsc22d1 are annotated in mouse and rat; check the datasheet of any product for its validated reactivity. A single nucleotide polymorphism in the human gene promoter has been associated with diabetic nephropathy, and the protein may act in tumour suppression.
Other TSC22 domain family members and tuberous sclerosis complex proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15714; product specifications from Assay Genie datasheets.