CHD5
CHD5 (chromodomain helicase DNA binding protein 5) is an ATP-dependent chromatin-remodelling factor that binds DNA through histones and regulates gene transcription. It is a neuron-specific member of the chromodomain helicase DNA-binding family and a potential tumour suppressor. Browse Assay Genie's current range of CHD5 research reagents below, or read on for the biology behind the target.
CHD5 is an ATP-dependent chromatin remodeller that binds DNA through histones and regulates gene transcription. It may specifically recognise trimethylated Lys-27 (H3K27me3) and non-methylated Lys-4 of histone H3. It acts as a component of the histone deacetylase NuRD complex, which participates in the remodelling of chromatin. In the developing nervous system, CHD5 activates the expression of genes that promote terminal neuronal differentiation. In parallel, it may positively regulate trimethylation of histone H3 at Lys-27, thereby repressing genes that drive differentiation into non-neuronal cell lineages.
The CHD5 gene encodes a member of the chromodomain helicase DNA-binding protein family, whose members are characterised by a chromodomain, a helicase ATP-binding domain and an additional functional domain. The protein belongs to the SNF2/RAD54 helicase family, and HGNC places it among the PHD finger proteins, the SNF2 related family and the NuRD complex subunits. NCBI Gene describes it as a neuron-specific protein. Mouse and rat orthologs, both named Chd5, are recognised.
CHD5 regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A, which positively regulates the p53/TP53 pathway and in turn prevents cell proliferation. This is consistent with the designation of the CHD5 gene as a potential tumour suppressor that may play a role in the development of neuroblastoma. In spermatogenesis, CHD5 probably regulates histone hyperacetylation and the replacement of histones by transition proteins, a crucial step in condensing spermatid chromatin and producing functional spermatozoa.
CHD5 is an ATP-dependent remodeller that binds DNA through histones and is a component of the NuRD complex, making it relevant to chromatin regulation studies.
CHD5 activates genes that promote neuron terminal differentiation and may repress genes driving non-neuronal lineages, linking it to nervous system development.
CHD5 is a potential tumour suppressor gene that may play a role in neuroblastoma, and may act through CDKN2A and the p53 pathway.
CHD5 probably regulates histone hyperacetylation and histone replacement by transition proteins, a key step in spermatid chromatin condensation.
CHD5 is an ATP-dependent chromatin remodeller that binds DNA through histones and regulates transcription. As part of the NuRD complex it participates in chromatin remodelling. It promotes expression of genes for neuronal terminal differentiation and regulates genes involved in cell proliferation and differentiation.
CHD5 is a chromodomain helicase DNA-binding protein and belongs to the SNF2/RAD54 helicase family. HGNC groups it with PHD finger proteins, the SNF2 related family and NuRD complex subunits. It has no listed alternative symbols or previous names.
NCBI Gene describes the CHD5 gene as a potential tumour suppressor that may play a role in neuroblastoma. UniProt notes that it may activate CDKN2A, which positively regulates the p53 pathway. Mouse and rat both have a Chd5 ortholog; check the datasheet of any product for its validated reactivity.
Other chromodomain helicase DNA-binding proteins and chromatin-remodelling family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TDI0; product specifications from Assay Genie datasheets.