CEACAM6
CEACAM6 (CEA cell adhesion molecule 6, also known as CD66c, NCA-50/90 and NCA) is a GPI-anchored cell surface glycoprotein of the carcinoembryonic antigen family. It mediates cell adhesion and has roles in cell migration and tumour progression. Browse Assay Genie's current range of CEACAM6 research reagents below, or read on for the biology behind the target.
CEACAM6 is a cell surface glycoprotein that plays a role in cell adhesion and tumour progression. Intercellular adhesion mediated by the protein occurs in a calcium- and fibronectin-independent manner. It supports both homophilic adhesion and heterophilic adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. The interaction with CEACAM8 occurs in activated neutrophils. CEACAM6 also contributes to neutrophil adhesion to cytokine-activated endothelial cells, and to cell migration and adhesion to endothelial cells.
The CEACAM6 gene encodes a member of the carcinoembryonic antigen (CEA) family, whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. The protein belongs to the immunoglobulin superfamily and localises to the cell membrane, including the apical cell membrane. The gene sits within a cluster of genes and pseudogenes of the cell adhesion molecule subgroup of the CEA family on chromosome 19. HGNC classes it among CD molecules, V-set domain containing proteins and the CEA cell adhesion molecule family.
Members of the CEA family are widely used as tumour markers in serum immunoassay determinations of carcinoma, which makes the CEACAM6 protein a common subject in cancer research. The gene also affects the sensitivity of tumour cells to adenovirus infection. In patients with Crohn's disease, CEACAM6 acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells. Previous names include carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen).
CEACAM6 plays a role in tumour progression, and CEA family members are widely used as serum tumour markers in carcinoma immunoassays.
The protein mediates homophilic and heterophilic adhesion independently of calcium and fibronectin, and contributes to cell migration.
CEACAM6 interacts with CEACAM8 in activated neutrophils and supports neutrophil adhesion to cytokine-activated endothelial cells.
CEACAM6 acts as a receptor for adherent-invasive E. coli on ileal epithelial cells in Crohn's disease and affects tumour cell sensitivity to adenovirus.
CEACAM6 is a cell surface glycoprotein that mediates cell adhesion, including homophilic binding and heterophilic binding with CEACAM5 and CEACAM8. It contributes to neutrophil adhesion to activated endothelial cells, cell migration and tumour progression. Adhesion does not depend on calcium or fibronectin.
CEACAM6 is also called CD66c, NCA-50/90 and NCA. Its full HGNC name is CEA cell adhesion molecule 6, and an earlier name was carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen). UniProt lists it as cell adhesion molecule CEACAM6.
The NCBI Gene summary notes that CEA family members are used as tumour markers in carcinoma serum immunoassays. CEACAM6 also acts as a receptor for adherent-invasive E. coli on ileal epithelial cells in Crohn's disease, and it affects tumour cell sensitivity to adenovirus infection.
Other CEA family cell adhesion molecules with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P40199; product specifications from Assay Genie datasheets.