LSS
LSS (lanosterol synthase, also known as OSC) is an endoplasmic reticulum membrane enzyme of the terpene cyclase/mutase family. It catalyses the cyclisation of (S)-2,3 oxidosqualene to lanosterol, a key step in cholesterol biosynthesis. Browse Assay Genie's current range of LSS research reagents below, or read on for the biology behind the target.
LSS is a key enzyme in the cholesterol biosynthesis pathway. It catalyses the cyclisation of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. According to the NCBI Gene summary, this is the first step in the biosynthesis of cholesterol, steroid hormones and vitamin D. Through the production of lanosterol, LSS may also regulate lens protein aggregation and increase lens transparency.
The LSS protein is located in the endoplasmic reticulum membrane and belongs to the terpene cyclase/mutase family. Its enzymatic activity is classified as EC 5.4.99.7. The human LSS gene is orthologous to mouse and rat Lss, and alternative splicing is reported to give rise to multiple transcript variants encoding different isoforms.
The enzyme has also been named 2,3-oxidosqualene-lanosterol cyclase, and the alias OSC (oxidosqualene cyclase) is still found in the literature. Because it sits at the branch point that commits squalene-derived precursors to the sterol nucleus, lanosterol synthase is a useful focus for studies of sterol metabolism and of lanosterol-related effects on lens protein aggregation.
LSS catalyses the cyclisation of (S)-2,3 oxidosqualene to lanosterol, making it a central enzyme for studying the cholesterol biosynthesis pathway.
As the first step towards cholesterol, steroid hormones and vitamin D, LSS is relevant to research on the origins of these sterol-derived molecules.
Lanosterol produced by LSS may regulate lens protein aggregation and increase transparency, linking the enzyme to studies of lens biology.
LSS is a member of the terpene cyclase/mutase family, and forms the sterol nucleus in a single cyclisation reaction.
LSS, or lanosterol synthase, catalyses the cyclisation of (S)-2,3 oxidosqualene to lanosterol, forming the sterol nucleus. This is the first step in the biosynthesis of cholesterol, steroid hormones and vitamin D. It may also regulate lens protein aggregation and increase transparency.
LSS is also known as OSC, and an earlier HGNC name is lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase). The NCBI Gene summary states that alternative splicing results in multiple transcript variants encoding different isoforms.
Yes. The human LSS gene has orthologues named Lss in both mouse and rat. Always check the datasheet of any product for its validated reactivity before using it with a particular species.
Other sterol biosynthesis enzymes and cholesterol metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P48449; product specifications from Assay Genie datasheets.