FBLN7
FBLN7 (fibulin 7, also known as TM14 and FLJ37440) is a secreted extracellular matrix protein of the fibulin family. It acts as an adhesion molecule that interacts with matrix components in developing teeth. Browse Assay Genie's current range of FBLN7 research reagents below, or read on for the biology behind the target.
FBLN7 is an adhesion molecule that interacts with extracellular matrix molecules in developing teeth. According to UniProt, it may play important roles in the differentiation and maintenance of odontoblasts, the cells that form dentin, as well as in dentin formation itself. The protein is secreted and found in the extracellular space, where it is part of the extracellular matrix.
The FBLN7 gene encodes fibulin-7, a member of the fibulin family. HGNC classifies it within the fibulins and the Sushi domain containing gene groups. NCBI Gene summarises its activities as predicted rather than established: calcium ion binding, heparan sulfate proteoglycan binding and heparin binding. It is also predicted to be involved in cell adhesion and is reported to be located in focal adhesions. Researchers studying FBLN7 protein often examine it in the context of matrix-cell contacts and tooth development.
The gene is also known as TM14 and FLJ37440, and these aliases may appear in older literature and database records. A mouse ortholog, Fbln7, is recorded, which supports comparative work on matrix biology and dental development. Fibulin family members such as FBLN1, FBLN2 and FBLN5 provide useful reference points when comparing matrix-binding behaviour across the family.
FBLN7 interacts with matrix molecules in developing teeth, making it relevant to studies of tooth formation.
The protein may contribute to odontoblast differentiation and maintenance, and to dentin formation.
FBLN7 is an adhesion molecule predicted to be involved in cell adhesion and located in focal adhesions.
As a secreted fibulin predicted to bind calcium, heparin and heparan sulfate proteoglycan, it is relevant to matrix interaction studies.
FBLN7 is an adhesion molecule that interacts with extracellular matrix molecules in developing teeth. UniProt notes it may be important for the differentiation and maintenance of odontoblasts and for dentin formation. It is secreted into the extracellular matrix.
FBLN7 is the HGNC symbol for fibulin 7, and the UniProt protein name is fibulin-7. Aliases and previous symbols include TM14 and FLJ37440. Searching under all of these names helps when reviewing older publications and database entries.
A mouse ortholog, Fbln7, is recorded for the human gene. FBLN7 belongs to the fibulin family, which also includes FBLN1, FBLN2 and FBLN5. Check the datasheet of any product for its validated reactivity.
Other fibulin family members and extracellular matrix proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q53RD9; product specifications from Assay Genie datasheets.