NLRC5
NLRC5 (NLR family CARD domain containing 5, also known as NOD27, CLR16.1 and FLJ21709) is a cytoplasmic member of the NLR family. It is a probable regulator of NF-kappa-B and type I interferon signalling, with roles in innate immunity and antiviral defence. Browse Assay Genie's current range of NLRC5 research reagents below, or read on for the biology behind the target.
NLRC5 is a probable regulator of the NF-kappa-B and type I interferon signalling pathways. It may also regulate type II interferon signalling. Functionally, it contributes to the homeostatic control of innate immunity and to antiviral defence mechanisms. According to the NCBI Gene summary, it acts in cytokine responses and antiviral immunity through inhibition of NF-kappa-B activation and negative regulation of type I interferon signalling.
The NLRC5 gene encodes a member of the caspase recruitment domain-containing NLR family, and HGNC places it in the NLR family gene group. The protein localises to the cytoplasm. UniProt lists it under the NLRP family annotation, and a mouse ortholog, Nlrc5, is recorded. Researchers studying the NLRC5 protein therefore often place it alongside other NLR proteins such as NLRC4 when examining innate immune sensing.
The target is also catalogued under the aliases NOD27, CLR16.1 and FLJ21709, so literature searches should cover all of these names. Because its reported activity centres on restraining NF-kappa-B and interferon signalling, NLRC5 is of interest wherever the balance between antiviral responses and immune homeostasis is under investigation.
NLRC5 contributes to homeostatic control of innate immunity, making it relevant to studies of how NLR family proteins shape immune responses.
NLRC5 has a documented role in antiviral defence mechanisms and antiviral immunity, supporting work on host responses to viral infection.
NLRC5 is a probable regulator of NF-kappa-B, and is reported to inhibit NF-kappa-B activation, informing studies of inflammatory signalling control.
NLRC5 negatively regulates type I interferon signalling and may influence type II signalling, relevant to cytokine response research.
NLRC5 is a probable regulator of the NF-kappa-B and type I interferon signalling pathways, and it may also regulate type II interferon signalling. It contributes to homeostatic control of innate immunity and to antiviral defence. NCBI describes it as inhibiting NF-kappa-B activation and negatively regulating type I interferon signalling.
The HGNC name is NLR family CARD domain containing 5, and UniProt uses Protein NLRC5. Aliases and previous symbols include NOD27, CLR16.1 and FLJ21709. It belongs to the NLR family, and the gene encodes a caspase recruitment domain-containing member of that family.
A mouse ortholog, Nlrc5, is recorded for the human gene. No rat ortholog is given in the data used here. Researchers working in other species should check the datasheet of any product for its validated reactivity.
Other NLR family members and innate immune signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86WI3; product specifications from Assay Genie datasheets.