DSPP
DSPP (dentin sialophosphoprotein, also known as DMP3, DFNA39 and DGI1) is a secreted extracellular matrix protein of the SIBLING family. It is processed into dentin sialoprotein and dentin phosphoprotein, two principal components of tooth dentin. Browse Assay Genie's current range of DSPP research reagents below, or read on for the biology behind the target.
The DSPP gene encodes a preproprotein that is secreted by odontoblasts and proteolytically processed into two principal proteins of the dentin extracellular matrix: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). The two products may play distinct but related roles in dentin mineralisation. DSP may be an important factor in dentinogenesis, while DPP may bind large amounts of calcium, facilitate the initial mineralisation of dentin matrix collagen, and regulate the size and shape of the crystals formed.
The DSPP protein is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family, and the human gene lies in a gene cluster on chromosome 4. Allelic differences arising from repeat polymorphisms have been reported for this gene. The mouse and rat orthologs are both named Dspp, which allows the protein to be studied in common rodent models of tooth development.
DSPP is also known as DMP3, DFNA39 and DGI1. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia, which makes dentin sialophosphoprotein a focus for researchers studying heritable disorders of tooth structure and the biology of the dentin extracellular matrix.
DSP may be an important factor in dentinogenesis, making DSPP a relevant target for studying how dentin forms.
DPP may bind high amounts of calcium and facilitate initial mineralisation of dentin matrix collagen, regulating crystal size and shape.
Mutations in DSPP are associated with dentinogenesis imperfecta and dentin dysplasia, supporting work on the genetics of dentin defects.
DSPP is secreted by odontoblasts and processed into two dentin matrix proteins, offering a model for matrix protein maturation.
DSPP is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. DSP may be important in dentinogenesis, while DPP may bind high amounts of calcium, facilitate initial mineralisation of dentin matrix collagen and regulate crystal size and shape.
The official name is dentin sialophosphoprotein, and aliases include DMP3, DFNA39 and DGI1. The preproprotein yields two products, dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), which are often discussed separately in the literature.
Mouse and rat both have a Dspp ortholog, so rodent models are commonly used. In humans, mutations in the gene are associated with dentinogenesis imperfecta and dentin dysplasia. Check the datasheet of any product for its validated reactivity.
Other SIBLING family members and mineralised-tissue matrix proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NZW4; product specifications from Assay Genie datasheets.