TINF2
TINF2 (TERF1-interacting nuclear factor 2, also known as TIN2) is a component of the shelterin complex, or telosome, which regulates telomere length and protects chromosome ends. It is important for assembly of the complex and is linked to dyskeratosis congenita. Browse Assay Genie's current range of TINF2 research reagents below, or read on for the biology behind the target.
TINF2 is a component of the shelterin complex (telosome), which is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without this protective activity, telomeres are no longer hidden from DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways. Shelterin therefore allows the cell to distinguish telomeres from regions of DNA damage.
Within the complex, TINF2 plays a role in shelterin assembly. According to the RefSeq summary, it is a critical part of shelterin and interacts with the three DNA-binding proteins of the complex. UniProt annotates the protein as localised to the nucleus, at the telomere of the chromosome, and in the nuclear matrix. Isoform 1 may have an additional role in tethering telomeres to the nuclear matrix. The mouse ortholog is Tinf2, and researchers studying the TINF2 gene or TINF2 protein often work across both species.
The protein was originally named TERF1 (TRF1)-interacting nuclear factor 2, and the alias TIN2 remains in common use. HGNC places the gene in the shelterin complex gene group. Mutations in the TINF2 gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome, which ties telomere protection to human disease.
TINF2 is part of the shelterin complex that regulates telomere length and protects chromosome ends from inappropriate processing.
TINF2 is important for assembling shelterin and interacts with its three DNA-binding proteins, making it a focus for complex architecture studies.
Shelterin hides telomeres from DNA damage surveillance and repair pathways, and TINF2 contributes to this distinction between telomeres and damaged DNA.
Mutations in TINF2 cause dyskeratosis congenita, an inherited bone marrow failure syndrome, so the protein is studied in telomere-related disease.
TINF2 is a component of the shelterin complex, which regulates telomere length and protects chromosome ends from being processed as DNA damage. It plays a role in shelterin assembly, and isoform 1 may also help tether telomeres to the nuclear matrix.
Yes. TIN2 is an alias for TINF2, and the previous name was TERF1 (TRF1)-interacting nuclear factor 2. The HGNC-approved name is TERF1 interacting nuclear factor 2. UniProt notes that isoform 1 may have an additional role at the nuclear matrix.
Mutations in TINF2 cause dyskeratosis congenita, an inherited bone marrow failure syndrome, according to the RefSeq summary. A mouse ortholog, Tinf2, exists; check the datasheet of any product for its validated reactivity.
Other shelterin complex members, telomerase components and dyskeratosis congenita-related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BSI4; product specifications from Assay Genie datasheets.