ZMAT3
ZMAT3 (zinc finger matrin-type 3, also known as WIG1, WIG-1 and PAG608) is a nuclear zinc finger protein that acts as a bona fide target of p53/TP53. It is linked to the p53-dependent growth regulatory pathway. Browse Assay Genie's current range of ZMAT3 research reagents below, or read on for the biology behind the target.
ZMAT3 is a bona fide target gene of p53/TP53 and may play a role in the TP53-dependent growth regulatory pathway. It may also contribute to TP53-mediated apoptosis by regulating TP53 expression and its translocation to the nucleus and nucleolus. Both the mRNA and the protein are upregulated by wildtype p53, and overexpression of the ZMAT3 gene inhibits tumour cell growth, which suggests a role in p53-dependent growth control.
The ZMAT3 protein contains three zinc finger domains and a nuclear localisation signal, in keeping with its localisation to the nucleus and nucleolus. HGNC places it in the matrin-type zinc finger gene group. Alternative splicing of the gene produces two transcript variants that encode two isoforms differing in only one amino acid.
The protein is also known as WIG-1 (WIG1), with further aliases including PAG608, MGC10613 and FLJ12296. Mouse and rat orthologues are both designated Zmat3. Because of its connection to p53 signalling, growth regulation and apoptosis, ZMAT3 is of interest to researchers studying p53 biology and tumour cell growth control.
ZMAT3 is a bona fide p53 target, so it serves as a readout of p53-dependent transcriptional responses.
Overexpression of ZMAT3 inhibits tumour cell growth, making it relevant to studies of p53-dependent growth control.
ZMAT3 may contribute to TP53-mediated apoptosis by regulating TP53 expression and its translocation to the nucleus and nucleolus.
With three zinc finger domains and a nuclear localisation signal, ZMAT3 is a model for matrin-type zinc finger proteins in the nucleus.
ZMAT3 is a bona fide target gene of p53/TP53 and may play a role in the TP53-dependent growth regulatory pathway. It may contribute to TP53-mediated apoptosis by regulating TP53 expression and its translocation to the nucleus and nucleolus.
ZMAT3 is also called WIG1, WIG-1, PAG608, MGC10613 and FLJ12296. Alternative splicing gives two transcript variants encoding two isoforms that differ in only one amino acid. Check the datasheet of any product for its validated reactivity.
Mouse and rat both have a Zmat3 orthologue. In human cells, ZMAT3 mRNA and protein are upregulated by wildtype p53, and overexpression inhibits tumour cell growth, supporting a role in the p53-dependent growth regulatory pathway.
p53 pathway proteins and other zinc finger targets relevant to growth regulation and apoptosis research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HA38; product specifications from Assay Genie datasheets.