MAP4
MAP4 (microtubule associated protein 4) is a major non-neuronal microtubule-associated protein that promotes microtubule assembly. It sits in the cytoskeleton, where its phosphorylation influences microtubule properties and cell cycle progression. Browse Assay Genie's current range of MAP4 research reagents below, or read on for the biology behind the target.
MAP4 is a major non-neuronal microtubule-associated protein. Its core function is to promote microtubule assembly, and it has been shown to counteract the destabilisation of interphase microtubules caused by promotion of microtubule catastrophe. In this way the MAP4 protein helps to maintain the microtubule network of non-neuronal cells.
The MAP4 gene encodes a protein with a domain similar to the microtubule-binding domains of the neuronal microtubule-associated proteins MAP2 and tau (MAPT). UniProt places the protein in the cytoplasmic cytoskeleton and in the microtubule organising centre. Multiple transcript variants encoding different isoforms have been reported for the gene. The mouse and rat orthologues are both named Map4.
MAP4 also links microtubules to the cell cycle. Cyclin B interacts with it, and this interaction targets the CDC2 (cell division cycle 2) kinase to microtubules. Phosphorylation of MAP4 affects microtubule properties and cell cycle progression, which makes it a useful subject for studies of microtubule regulation and mitotic control. Researchers working on the MAP4 gene or protein often compare it with MAP2 and tau to explore how related microtubule-binding domains behave in neuronal and non-neuronal settings.
MAP4 promotes microtubule assembly and counteracts destabilisation of interphase microtubules, making it central to studies of microtubule stability.
Phosphorylation of MAP4 affects microtubule properties and cell cycle progression, linking the cytoskeleton to division control.
Cyclin B interacts with MAP4, which targets CDC2 kinase to microtubules, offering a route to study mitotic kinase localisation.
MAP4 shares microtubule-binding domain features with MAP2 and tau, supporting comparisons between non-neuronal and neuronal microtubule-associated proteins.
MAP4 is a major non-neuronal microtubule-associated protein that promotes microtubule assembly. It has been shown to counteract destabilisation of interphase microtubules by catastrophe promotion. Its phosphorylation affects microtubule properties and cell cycle progression, and it binds cyclin B to target CDC2 kinase to microtubules.
The HGNC name is microtubule associated protein 4, and UniProt uses Microtubule-associated protein 4; no other aliases or previous symbols are listed. NCBI Gene reports multiple transcript variants encoding different isoforms, so check the datasheet of any product for its validated reactivity.
Yes. MAP4 contains a domain similar to the microtubule-binding domains of neuronal MAP2 and tau (MAPT), although MAP4 is the major non-neuronal member. Mouse and rat both carry a Map4 orthologue; check the datasheet of any product for its validated reactivity.
Other microtubule-associated proteins and MAP-named kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P27816; product specifications from Assay Genie datasheets.