SMC1A
SMC1A (structural maintenance of chromosomes 1A, also known as SMC1L1, KIAA0178 and SB1.8) is a central component of the cohesin complex. It holds sister chromatids together after DNA replication and contributes to DNA repair and S-phase checkpoint signalling. Browse Assay Genie's current range of SMC1A research reagents below, or read on for the biology behind the target.
SMC1A is involved in chromosome cohesion during the cell cycle and in DNA repair. It is a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesin may also play a role in spindle pole assembly during mitosis.
Proper sister chromatid cohesion is a prerequisite for correct chromosome segregation during cell division. The cohesin complex is composed partly of two SMC proteins: SMC3 and either SMC1B or the protein encoded by the SMC1A gene. Most cohesin complexes leave the chromosomes before mitosis, but those at the kinetochore remain, so SMC1A is thought to be an important part of functional kinetochores. The protein belongs to the SMC family, SMC1 subfamily, and is found in the nucleus, on chromosomes and at the centromeric kinetochore.
SMC1A also acts in the DNA damage response. It interacts with BRCA1 and is phosphorylated by ATM, or by ATR, and it works as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of the S-phase checkpoint. The gene lies in a region of the X chromosome that escapes X inactivation, and mutations in it result in Cornelia de Lange syndrome. Alternative splicing gives multiple transcript variants encoding different isoforms. Earlier names include SMC1 structural maintenance of chromosomes 1-like 1 (yeast), and mouse and rat orthologs are both named Smc1a.
SMC1A is part of the cohesin ring that keeps sister chromatids together until anaphase, making it central to studies of faithful chromosome segregation.
Phosphorylation of SMC1A by ATM and ATR, and its interaction with BRCA1, link it to DNA repair and S-phase checkpoint research.
Cohesin at the kinetochore persists before mitosis, and SMC1A is thought to be an important part of functional kinetochores and spindle pole assembly.
Mutations in the SMC1A gene result in Cornelia de Lange syndrome, making it a focus for cohesin-related developmental disorder research.
SMC1A is a central component of the cohesin complex, which is required for cohesion of sister chromatids after DNA replication. It is also involved in DNA repair and acts downstream of ATM/NBS1 and ATR/MSH2 in the S-phase checkpoint.
SMC1A is also called SMC1L1, SB1.8, Smcb, DXS423E and KIAA0178. Earlier names were SMC1 (structural maintenance of chromosomes 1, yeast)-like 1. Alternative splicing gives multiple transcript variants encoding different isoforms.
Mutations in the SMC1A gene result in Cornelia de Lange syndrome. Orthologs are named Smc1a in both mouse and rat. Check the datasheet of any product for its validated reactivity.
Other structural maintenance of chromosomes proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14683; product specifications from Assay Genie datasheets.