BMPER
BMPER (BMP binding endothelial regulator, also known as Cv2 and CRIM3) is a secreted protein that interacts with and inhibits bone morphogenetic protein (BMP) function. It may regulate BMP responsiveness in osteoblasts and chondrocytes. Browse Assay Genie's current range of BMPER research reagents below, or read on for the biology behind the target.
BMPER is an inhibitor of bone morphogenetic protein (BMP) function. The secreted protein interacts with BMPs and is thought to regulate how responsive osteoblasts and chondrocytes are to BMP signalling. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation, as well as BMP-dependent differentiation of chondrogenic cells.
The human BMPER gene encodes the BMP-binding endothelial regulator protein, which is released from the cell and acts extracellularly. HGNC places it in the group of cysteine rich transmembrane BMP regulators. The mouse ortholog is named Bmper. Researchers studying BMP biology may look at BMPER protein as a modulator of ligand activity rather than as a receptor or a signalling effector.
The gene is also known as Cv2 and CRIM3. Mutations in the BMPER gene are associated with diaphanospondylodysostosis, a lethal skeletal disorder, which links the protein to skeletal development. Its role in restraining BMP-driven differentiation makes it a useful target for work on bone and cartilage formation and on the control of BMP pathway output.
BMPER inhibits BMP function, making it relevant to studies of how BMP activity is restrained in the extracellular environment.
BMPER inhibits BMP2- and BMP4-dependent osteoblast differentiation, so it is relevant to research on bone-forming cells.
BMPER inhibits BMP-dependent differentiation of chondrogenic cells and may regulate BMP responsiveness of chondrocytes.
Mutations in BMPER are associated with diaphanospondylodysostosis, a lethal skeletal disorder, supporting its use in skeletal disease studies.
BMPER is a secreted protein that interacts with and inhibits bone morphogenetic protein (BMP) function. It inhibits BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of chondrogenic cells, and it may regulate BMP responsiveness of osteoblasts and chondrocytes.
BMPER stands for BMP binding endothelial regulator. The gene has also been called Cv2 and CRIM3, and the UniProt entry names the product BMP-binding endothelial regulator protein. Alternative names may appear in older literature, so searching under all of them is worthwhile.
Mutations in the BMPER gene are associated with diaphanospondylodysostosis, a lethal skeletal disorder. A mouse ortholog, Bmper, exists, so mouse models can be used for related work. Check the datasheet of any product for its validated reactivity.
Other BMP ligands, receptors, extracellular BMP antagonists and pathway markers relevant to bone and cartilage research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N8U9; product specifications from Assay Genie datasheets.