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CDC42EP2
CDC42EP2 (CDC42 effector protein 2, also known as CEP2 and BORG1) is a member of the Borg family of CDC42 effector proteins. It is probably involved in organising the actin cytoskeleton and acts in connection with the small Rho GTPase CDC42. Browse Assay Genie's current range of CDC42EP2 research reagents below, or read on for the biology behind the target.
CDC42EP2 is probably involved in the organisation of the actin cytoskeleton. It may act downstream of CDC42 to induce actin filament assembly, leading to changes in cell shape. In fibroblasts, the protein induces pseudopodia formation in a CDC42-dependent manner. Co-expression of CDC42EP2 with CDC42 pointed to a role in actin filament assembly and in the control of cell shape.
CDC42 is a small Rho GTPase that regulates the formation of F-actin-containing structures through its interaction with downstream effector proteins. The CDC42EP2 gene encodes one such effector and belongs to the BORG/CEP family, known as the Borg family. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and negatively regulate its function. The CDC42EP2 protein is assigned to the endomembrane system and the cytoplasmic cytoskeleton.
The gene is listed by HGNC within the group of CDC42 effector proteins. It was previously named CDC42 effector protein (Rho GTPase binding) 2, and is also known by the aliases CEP2 and BORG1. Mouse and rat both carry an orthologous gene, Cdc42ep2, which allows the protein to be studied in rodent models of cytoskeletal regulation.
CDC42EP2 is probably involved in organising the actin cytoskeleton and may drive actin filament assembly downstream of CDC42.
Co-expression with CDC42 suggests a role for this protein in controlling cell shape through actin filament assembly.
As a CRIB domain-containing Borg family effector, it binds CDC42 and negatively regulates its function, making it useful for studying GTPase signalling.
The protein induces pseudopodia formation in fibroblasts in a CDC42-dependent manner, offering a handle on cell protrusion mechanisms.
CDC42EP2 is probably involved in organising the actin cytoskeleton. It may act downstream of CDC42 to induce actin filament assembly and cell shape changes, and it induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. As a Borg family protein, it also binds and negatively regulates CDC42.
CDC42EP2 stands for CDC42 effector protein 2, and UniProt lists it as Cdc42 effector protein 2. Aliases and previous symbols include CEP2 and BORG1. An earlier name was CDC42 effector protein (Rho GTPase binding) 2. It belongs to the BORG/CEP family.
Yes. Both mouse and rat have an ortholog named Cdc42ep2, so the protein can be studied in rodent systems. Check the datasheet of any product for its validated reactivity.
CDC42, other CDC42 effector proteins and related cell division cycle targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14613; product specifications from Assay Genie datasheets.
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