ADAMTS12
ADAMTS12 (a disintegrin and metalloproteinase with thrombospondin motifs 12) is a secreted metalloprotease of the ADAMTS family, found in the extracellular matrix. It may contribute to degradation of COMP, cleaves alpha-2 macroglobulin and aggrecan, and has anti-tumorigenic properties. Browse Assay Genie's current range of ADAMTS12 research reagents below, or read on for the biology behind the target.
ADAMTS12 is a metalloprotease that may play a role in the degradation of COMP (cartilage oligomeric matrix protein). It also cleaves alpha-2 macroglobulin and aggrecan, and has been described as having anti-tumorigenic properties. The protein is secreted and localises to the extracellular space and extracellular matrix, where it acts on matrix components through its proteolytic activity.
The ADAMTS12 gene encodes a member of the ADAMTS protein family, classed by HGNC in the group of ADAM metallopeptidases with thrombospondin type 1 motif. Family members share several protein modules: a propeptide region, a metalloproteinase domain, a disintegrin-like domain and a thrombospondin type 1 (TS-1) motif. Individual members differ in the number of C-terminal TS-1 motifs, and some carry unique C-terminal domains. The ADAMTS12 enzyme contains eight TS-1 motifs. The mouse ortholog is Adamts12, which is relevant when choosing a model for functional studies.
According to the NCBI Gene summary, ADAMTS12 may play roles in pulmonary cells during foetal development, or in tumour processes through its proteolytic activity. It may also be a molecule involved in the regulation of cell adhesion. The approved gene name was previously written as a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12. Researchers studying ADAMTS12 typically examine matrix substrate cleavage, cell adhesion and tumour biology, using tools such as an ADAMTS12 antibody, ADAMTS12 ELISA kit or recombinant ADAMTS12 protein.
ADAMTS12 may degrade COMP and cleaves aggrecan, making it a protease of interest in studies of matrix component breakdown.
ADAMTS12 has anti-tumorigenic properties and may act in tumour processes through its proteolytic activity.
ADAMTS12 may play roles in pulmonary cells during foetal development, according to the NCBI Gene summary.
ADAMTS12 is a potential regulator of cell adhesion, linking its protease activity to cell-matrix interactions.
ADAMTS12 is a secreted metalloprotease that may contribute to the degradation of COMP. It also cleaves alpha-2 macroglobulin and aggrecan, and has anti-tumorigenic properties. It may also play roles in foetal pulmonary cells and in regulating cell adhesion.
ADAMTS12 stands for a disintegrin and metalloproteinase with thrombospondin motifs 12. It has a propeptide region, a metalloproteinase domain, a disintegrin-like domain and eight thrombospondin type 1 motifs. No other gene symbols are recorded by HGNC for it.
The mouse has an ortholog named Adamts12, so rodent models can be used to study the gene. Rat ortholog information is not given in the data here. Please check the datasheet of any product for its validated reactivity.
Other ADAMTS family metalloproteases involved in extracellular matrix processing, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P58397; product specifications from Assay Genie datasheets.