MMRN2
MMRN2 (multimerin 2) is a secreted extracellular matrix glycoprotein that influences angiogenesis and belongs to the EMILIN protein family. It is also known as EndoGlyx-1, EMILIN3 and FLJ13465, and it acts as a ligand for the CD93 receptor. Browse Assay Genie's current range of MMRN2 research reagents below, or read on for the biology behind the target.
MMRN2 is an extracellular matrix protein that affects several essential steps in angiogenesis, including endothelial cell proliferation, migration and tube formation. It positively regulates angiogenesis by acting as a ligand for the CD93 receptor. The MMRN2 protein is secreted into the extracellular space, where it becomes part of the extracellular matrix.
The MMRN2 gene encodes a member of the elastin microfibril interface-located (EMILIN) protein family. HGNC places it in the EMI domain containing and C1q domain containing gene groups. According to the NCBI Gene summary, this glycoprotein can interfere with tumour angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. The mouse ortholog is Mmrn2.
The gene was previously named elastin microfibril interfacer 3, which is why EMILIN3 is still used as an alias, alongside EndoGlyx-1 and FLJ13465. Its relative MMRN1 (multimerin 1) shares the multimerin name. Researchers studying vascular biology, matrix-mediated signalling and tumour angiogenesis use MMRN2 antibody, MMRN2 ELISA kit and MMRN2 protein reagents to investigate how this matrix component shapes endothelial behaviour.
MMRN2 affects endothelial cell proliferation, migration and tube formation, making it a relevant protein for studying the steps of new blood vessel formation.
The MMRN2 glycoprotein can interfere with tumour angiogenesis and growth, so it is studied in the context of the tumour vasculature.
MMRN2 acts as a ligand for the CD93 receptor and positively regulates angiogenesis through this interaction.
MMRN2 can interfere with the VEGF-A/VEGFR2 pathway and acts as a transforming growth factor beta antagonist.
MMRN2 is an extracellular matrix protein that affects endothelial cell proliferation, migration and tube formation during angiogenesis. It positively regulates angiogenesis as a ligand for the CD93 receptor, and it can also interfere with the VEGF-A/VEGFR2 pathway and antagonise transforming growth factor beta.
The MMRN2 gene (multimerin 2) is also known as EndoGlyx-1, FLJ13465 and EMILIN3. The EMILIN3 alias reflects its previous name, elastin microfibril interfacer 3, and its place in the EMILIN protein family. UniProt lists the protein as Multimerin-2.
A mouse ortholog, Mmrn2, is recorded for the human gene. The NCBI Gene summary also notes a related pseudogene on chromosome 6. Check the datasheet of any product for its validated reactivity before planning cross-species work.
Multimerin family relatives and other extracellular matrix targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H8L6; product specifications from Assay Genie datasheets.