SYCP3
SYCP3 (synaptonemal complex protein 3) is an essential structural component of the synaptonemal complex, the structure that forms between homologous chromosomes during meiotic prophase. It is required for normal meiosis during spermatogenesis and for male fertility. Browse Assay Genie's current range of SYCP3 research reagents below, or read on for the biology behind the target.
SYCP3 is a component of the synaptonemal complex, which forms between homologous chromosomes during meiotic prophase. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes, and SYCP3 is an essential structural part of it. The protein is required for centromere pairing during meiosis in male germ cells, and it is needed for efficient phosphorylation of HORMAD1 and HORMAD2.
The human SYCP3 gene encodes a protein that localises to the nucleus, where it associates with chromosomes and the centromere. Alternate splicing produces multiple transcript variants, but all of them encode the same protein. SYCP3 belongs to the XLR/SYCP3 family. Mouse and rat both carry a Sycp3 ortholog, so rodent models are commonly used to study the function of the protein in meiosis.
SYCP3 is required for normal meiosis during spermatogenesis and for male fertility. It plays a lesser role in female fertility. Mutations in the SYCP3 gene are associated with azoospermia in males and with susceptibility to pregnancy loss in females. These links make SYCP3 a useful marker and study target in reproductive biology, germ cell research and the analysis of meiotic chromosome behaviour.
SYCP3 is a structural component of the synaptonemal complex, which mediates synapsis, recombination and segregation of meiotic chromosomes.
SYCP3 is required for normal meiosis during spermatogenesis and for centromere pairing in male germ cells.
Mutations in the SYCP3 gene are associated with azoospermia, making it a relevant gene in male fertility research.
SYCP3 plays a lesser role in female fertility, and mutations are linked to susceptibility to pregnancy loss.
SYCP3 is a component of the synaptonemal complex formed between homologous chromosomes in meiotic prophase. It is required for centromere pairing in male germ cells, for normal meiosis during spermatogenesis and for efficient phosphorylation of HORMAD1 and HORMAD2.
No alternative symbols or previous names are recorded for SYCP3 in the source data. Its full name is synaptonemal complex protein 3. Alternate splicing gives multiple transcript variants, but all of them encode the same protein, so there is a single protein sequence.
Mutations in SYCP3 are associated with azoospermia in males and susceptibility to pregnancy loss in females. Mouse and rat each have a Sycp3 ortholog. Check the datasheet of any product for its validated reactivity.
Other synaptonemal complex components and meiotic proteins that work alongside SYCP3 in germ cell research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IZU3; product specifications from Assay Genie datasheets.