SYCN
SYCN (syncollin) is a zymogen granule protein that functions in exocytosis in pancreatic acinar cells, where it regulates the fusion of zymogen granules with each other. It is also known as SYL, FLJ27441 and INSSA1. Browse Assay Genie's current range of SYCN research reagents below, or read on for the biology behind the target.
SYCN, or syncollin, functions in exocytosis in pancreatic acinar cells. In this setting it regulates the fusion of zymogen granules with each other, a step in the regulated release of digestive enzymes stored in these granules. UniProt also notes that syncollin may have pore-forming activity on membranes and may regulate exocytosis in other exocrine tissues, although this is described as a possibility rather than an established role.
The protein is annotated in two zymogen granule compartments, the granule membrane and the granule lumen. This fits its role in the granule fusion events that precede secretion. The NCBI Gene summary for the human SYCN gene similarly describes it as predicted to be involved in exocytosis and predicted to be located in the zymogen granule membrane. Orthologues are annotated in mouse and rat, both named Sycn, so the protein can be studied in rodent models of exocrine function.
The gene symbol SYCN is approved by HGNC for syncollin. Earlier literature and databases may use the aliases SYL, FLJ27441 and INSSA1, and the previous name insulin synthesis associated 1. Researchers searching for a syncollin antibody, SYCN ELISA kit or recombinant syncollin protein will often meet these older names, so it is worth checking all of them when reviewing prior work on zymogen granule exocytosis.
SYCN regulates fusion of zymogen granules with each other in pancreatic acinar cells, making it a relevant protein for studying enzyme secretion.
Syncollin is annotated as functioning in exocytosis, providing a defined protein for investigating how secretory granule fusion is controlled.
With annotation in both the granule membrane and lumen, SYCN is useful for examining the organisation and behaviour of zymogen granules.
UniProt suggests syncollin may regulate exocytosis in other exocrine tissues, an open question for comparative secretion studies.
SYCN functions in exocytosis in pancreatic acinar cells, regulating the fusion of zymogen granules with each other. UniProt also reports that it may have pore-forming activity on membranes and may regulate exocytosis in other exocrine tissues.
SYCN is the HGNC symbol for syncollin. Aliases include SYL, FLJ27441 and INSSA1, and the previous gene name was insulin synthesis associated 1. These names may appear in older papers and database entries.
Yes, orthologues of the human gene are annotated in both mouse and rat, and both are named Sycn. Cross-species work should still be planned carefully; check the datasheet of any product for its validated reactivity.
Other exocytosis and secretory granule proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q0VAF6; product specifications from Assay Genie datasheets.