MPEG1
MPEG1 (macrophage expressed 1, also known as P2, MPS-1 and MPG1) is a pore-forming protein that supports antigen cross-presentation in dendritic cells. It belongs to the MPEG1 family and is also linked to antibacterial defence responses. Browse Assay Genie's current range of MPEG1 research reagents below, or read on for the biology behind the target.
MPEG1 is a pore-forming protein with a central role in antigen cross-presentation in dendritic cells. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. MPEG1 acts by forming a pore in antigen-containing compartments, which promotes the release of antigens into the cytosol. This enables the generation of MHCI:peptide complexes and T-cell priming.
The MPEG1 protein is annotated in UniProt as a member of the MPEG1 family and is found at the cytoplasmic vesicle membrane, including the phagosome membrane, as well as in a secreted form. NCBI Gene describes it as enabling wide pore channel activity and as active in the phagolysosome membrane. The MPEG1 gene is named for its expression in macrophages, and its products are also known by the aliases P2, MPS-1 and MPG1; the mouse and rat orthologues are both designated Mpeg1.
Beyond antigen presentation, the MPEG1 gene is involved in defence responses to both Gram-negative and Gram-positive bacteria. It is also implicated in primary immunodeficiency disease. Together these annotations make MPEG1 a useful subject for studies of phagosomal biology, pore-forming proteins and the link between innate and adaptive immune function.
MPEG1 releases antigens from antigen-containing compartments into the cytosol, enabling MHC class-I loading and CD8(+) T-cell priming in dendritic cells.
As a mediator of antigen delivery, MPEG1 helps explain how dendritic cells connect innate antigen capture with adaptive T-cell responses.
MPEG1 is involved in defence responses to Gram-negative and Gram-positive bacteria and acts at the phagolysosome membrane.
MPEG1 is implicated in primary immunodeficiency disease, making it a candidate for studies of inherited defects in immune defence.
MPEG1 is a pore-forming protein that mediates antigen delivery for cross-presentation in dendritic cells. It forms a pore in antigen-containing compartments, releasing antigens into the cytosol so that MHCI:peptide complexes can form and naive CD8(+) T-cells can be primed.
The HGNC name is macrophage expressed 1, and UniProt lists the protein as macrophage-expressed gene 1 protein. Aliases and previous symbols include P2, MPS-1 and MPG1. The protein belongs to the MPEG1 family.
Mouse and rat both carry an orthologous gene named Mpeg1. In humans, MPEG1 is implicated in primary immunodeficiency disease and is involved in defence against Gram-negative and Gram-positive bacteria. Check the datasheet of any product for its validated reactivity.
Other pore-forming proteins, antigen-presentation components and innate immunity markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q2M385; product specifications from Assay Genie datasheets.