RCAN1
RCAN1 (regulator of calcineurin 1, also known as DSCR1 or calcipressin-1) is a member of the RCAN family that inhibits calcineurin-dependent transcriptional responses. It does so by binding the catalytic domain of calcineurin A. Browse Assay Genie's current range of RCAN1 research reagents below, or read on for the biology behind the target.
RCAN1 acts as an inhibitor of calcineurin signalling. According to UniProt, the protein inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. NCBI Gene describes the same interaction, noting that the protein inhibits calcineurin-dependent signalling pathways and may thereby affect central nervous system development. UniProt likewise states that it could play a role during central nervous system development.
The RCAN1 gene encodes a protein named calcipressin-1 in UniProt, and it belongs to the RCAN family, which HGNC lists as the regulator of calcineurin family. The gene is located at 21q22.12. Alternative splicing of the RCAN1 gene results in multiple transcript variants, so researchers working with this target should consider which transcript or protein form is relevant to their study. Mouse and rat each have an orthologous Rcan1 gene. RCAN2 is another member of the family.
The alias DSCR1 and the previous name Down syndrome critical region gene 1 reflect the position of the gene in the minimal candidate region for the Down syndrome phenotype. NCBI Gene reports that it is overexpressed in the brain of Down syndrome fetuses, and that chronic overexpression may lead to neurofibrillary tangles such as those associated with Alzheimer disease. These links make RCAN1 a recurring subject in studies of calcineurin signalling and neurological disease.
RCAN1 binds the catalytic domain of calcineurin A and inhibits calcineurin-dependent transcriptional responses, making it a key subject for studying this pathway.
UniProt and NCBI Gene both indicate that RCAN1 could play a role in central nervous system development through its effect on calcineurin signalling.
The gene lies in the minimal candidate region for the Down syndrome phenotype and is overexpressed in the brain of Down syndrome fetuses.
Chronic overexpression of RCAN1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease, according to NCBI Gene.
RCAN1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. It may also play a role during central nervous system development. Through this inhibition it modulates calcineurin-dependent signalling pathways.
RCAN1 is also called DSCR1, from its previous name Down syndrome critical region gene 1, and calcipressin-1 in UniProt. HGNC places it in the regulator of calcineurin family. Alternative splicing of the gene produces multiple transcript variants.
The RCAN1 gene lies in the minimal candidate region for the Down syndrome phenotype and is overexpressed in Down syndrome foetal brain. Chronic overexpression may lead to neurofibrillary tangles as seen in Alzheimer disease. Mouse and rat have Rcan1 orthologs; check the datasheet of any product for its validated reactivity.
Other members of the RCAN family and related calcineurin regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P53805; product specifications from Assay Genie datasheets.