LMO2
LMO2 (LIM domain only 2, also known as rhombotin-2, TTG2, RHOM2, RBTN2 and RBTNL1) is a nuclear, cysteine-rich protein with two LIM domains. It has a central role in haematopoietic development and in the regulation of red blood cell formation. Browse Assay Genie's current range of LMO2 research reagents below, or read on for the biology behind the target.
LMO2 acts with TAL1/SCL to regulate red blood cell development. It also acts with LDB1 to maintain erythroid precursors in an immature state. The protein localises to the nucleus, and the NCBI Gene summary describes it as having a central and crucial role in haematopoietic development. It is also required for yolk sac erythropoiesis, which makes the LMO2 protein a frequent subject in studies of blood cell lineage specification.
The human LMO2 gene encodes a cysteine-rich protein with two LIM domains and belongs to the HGNC gene group of LIM domain containing proteins. The protein is highly conserved, and the mouse ortholog is Lmo2. Alternative splicing of the LMO2 gene results in multiple transcript variants that encode different isoforms. Researchers working with an LMO2 antibody or LMO2 ELISA kit should therefore consider which isoforms are relevant to their question.
The name rhombotin-2 reflects the rhombotin nomenclature, and LMO2 was previously listed as rhombotin-like 1 (RBTNL1). Disease relevance centres on T-cell acute lymphoblastic leukaemia. The LMO2 transcription start site lies approximately 25 kb downstream of the 11p13 T-cell translocation cluster, where a number of T-ALL-specific translocations occur. This genomic position links LMO2 to the study of leukaemia-associated chromosomal rearrangements.
LMO2 has a central and crucial role in haematopoietic development and is highly conserved.
LMO2 is required for yolk sac erythropoiesis and acts with TAL1/SCL to regulate red blood cell development.
LMO2 acts with LDB1 to keep erythroid precursors in an immature state.
The LMO2 start site lies near the 11p13 translocation cluster where T-cell acute lymphoblastic leukaemia-specific translocations occur.
LMO2 acts with TAL1/SCL to regulate red blood cell development and with LDB1 to maintain erythroid precursors in an immature state. It is a nuclear protein that is required for yolk sac erythropoiesis and has a central role in haematopoietic development.
LMO2 is also called rhombotin-2, TTG2, RHOM2, RBTN2 and RBTNL1, and was previously named rhombotin-like 1. Alternative splicing produces multiple transcript variants that encode different isoforms, so check the datasheet of any product for its validated reactivity.
The LMO2 protein is highly conserved, and the mouse ortholog is Lmo2. Its transcription start site lies about 25 kb downstream of the 11p13 T-cell translocation cluster, where T-cell acute lymphoblastic leukaemia-specific translocations occur.
Other LIM domain only proteins and LMO2 partners in haematopoietic and erythroid regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P25791; product specifications from Assay Genie datasheets.